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Join host Paul Shapiro as he talks with some of the leading start-up entrepreneurs and titans of industry alike using their businesses to help solve the world’s most pressing problems. Whether it’s climate change, unsustainable agricultural practices, cyber threats, coral reef die-offs, nuclear waste storage, plastic pollution, or more, many of the world’s greatest challenges are also exciting business opportunities. On this show, we feature business leaders who are marrying profit and purpo ...
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In this episode, I’m joined by one of America’s most thoughtful national journalists: Mike Grunwald. You may know him from his work at Time, Politico, or The Washington Post, or from his critically acclaimed books about the Obama administration and the history of the Everglades. He’s also now a contributing columnist at the New York Times. But for …
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What if we could turn the mountains of food waste we generate every day into high-value chemicals that replace fossil fuels and palm oil—two of the most environmentally destructive inputs in our economy? That’s exactly what this episode’s guest is doing. Marc den Hartog is the CEO of ChainCraft, a Dutch biotechnology company using fermentation to c…
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This episode’s guest is someone who’s spent her career studying—and championing—entrepreneurs who don’t always fit the Silicon Valley mold. Dr. Lori Rosenkopf is the Vice Dean of Entrepreneurship at the Wharton School and the author of the new book Unstoppable Entrepreneurs: 7 Paths for Unleashing Successful Startups and Creating Value through Inno…
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You’ve heard of carbon capture machines, but what if one of the most powerful tools for removing CO₂ from the atmosphere isn’t high-tech at all—just crushed rock and rain? Meet Ana Pavlovic, CEO of Eion and the self-described “Crazy Rock Lady.” Her company is pioneering a process called enhanced rock weathering, which uses the natural properties of…
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In the restaurant world, infant mortality is the norm. Nearly two-thirds of new eateries shut down in their first year. Only one in five lives to see its fifth birthday. So when a restaurant—not just any restaurant, but a plant-based fine-dining spot—thrives for decades, it’s not just impressive. It’s almost mythic. Enter Rich Landau and Kate Jacob…
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Nick Cooney is one of the most prolific investors in food and ag tech. As the founder of Lever VC, he’s helped deploy nearly $80 million from his first fund and has now closed more than $50 million toward his second $100 million fund. He’s backed companies across the spectrum of sustainable protein—plant-based meat, cultivated meat, fermentation-de…
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Palm oil is everywhere—from food to cosmetics to biofuels—but its production is a leading cause of deforestation, habitat destruction, and greenhouse gas emissions. What if we could have all the benefits of palm oil without the downsides? Enter NoPalm Ingredients, a Dutch biotech startup using fermentation to produce a sustainable alternative to pa…
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What if the fat in your butter, cheese, or even burger could be made without animals, without plants, without fermentation, and without agriculture at all? That’s exactly what Savor is doing. Using a groundbreaking process that transforms compounds like CO₂ and elements like hydrogen into rich, animal-free fats that can mimic what animal fat does, …
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We spend about 90 percent of our lives indoors, yet the air inside our homes and offices is often far more polluted than the air outside. Volatile organic compounds—better known as VOCs—are constantly emitted by furniture, cleaning products, and even the very walls around us. Formaldehyde, benzene, toluene—these chemicals sound like something you’d…
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It’s no secret that the alternative protein startups are struggling these days. A combination of lower revenue, intense competition, and less available venture capital is leading to a contraction in the sector, with countless alt-meat and dairy companies conducting layoffs, declaring bankruptcy, and even folding altogether. Enter Ahimsa Companies, …
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Did you know that it takes 140 liters of water to make a single cup of coffee? Turns out that coffee, as far as plant crops are concerned, has a fairly heavy footprint on the planet. And it’s getting harder to farm, with climate change altering where and how many coffee beans can even be grown. You’ve heard of making meat without chickens, and milk…
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In this episode we’re diving deep into the fascinating world of carbon recycling with a trailblazer who’s reshaping how we think about waste and sustainability. Our guest is Dr. Jennifer Holmgren, CEO of LanzaTech—a company on a mission to transform our biggest environmental challenge into an economic opportunity. LanzaTech is pioneering a process …
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In this episode we’re taking you on a journey to some of the most remote corners of West Africa, where energy access is scarce, and innovation is changing lives. Our guest is Nicole Poindexter, the founder and CEO of Energicity, a company that's bringing clean, reliable solar power to off-grid communities in countries like Sierra Leone, Benin, and …
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Most plant-based meats in the US have centered around American staples like hamburgers, hot dogs, chicken nuggets, and sausages. But there’s a world of meat consumption out there, and some of the most popular meat dishes are ones many Americans may have never even tried. In recent years, South Korea has seen great success exporting its culture arou…
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Imagine trying to run a small business without a constant supply of energy. With electricity intermittency, you may not have access to wifi, a phone, a computer, a way to service your customers and more. One way to solve this problem is to have constant access to fossil fuels to run diesel generators, but this is an expensive and dirty way to opera…
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Eric Schulze loves the intersection of science and food so much that after many years as an FDA regulator, he decided in 2016 to leave the federal government to join the then-nascent Memphis Meats (now UPSIDE Foods). He’d go on to spend the next seven years working to advance the cultivated meat pioneer’s science, technology, communications, and ul…
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We all know chocolate is sweet. The way that it’s made—not so much. From deforestation and climate change to child labor and heavy metal contamination, cocoa farming leaves a lot to be desired. But what if we could make cocoa powder without having to chop down the rainforest and engage in so many other unsavory practices? That’s what California Cul…
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If you follow the world of cultivated meat, you probably know that a few companies have gotten historic regulatory approval and have sold some limited quantities of product both in the US and Singapore. But earlier this year, Meatly—a company founded only in 2021 and with just a few million British pounds in their pocket—succeeded in getting regula…
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Around the time his son was born in 2011, Beni Nofech saw a video that changed his life. After listening to an argument about the need to move away from the view that animals are mere commodities for humanity to use however we like, Beni adopted a vegan diet and soon found himself attending animal movement and alt-protein conferences. From there, h…
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You’ve heard of fruit leather, but what about making leather from fruit? Or more precisely, feeding fruit waste like mango pulp to bacteria which then convert those sugars into a leather-like material that can be useful for all types of purposes? That’s exactly what Polybion, a startup in Central Mexico, is doing. Co-founded in 2015 by two brothers…
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Alt-meat today is typically made from soybeans, yellow peas, wheat, or some combination of those three crops. But there’s a whole world of plants out there, and maybe some of them can be harnessed to widen the world of ingredients available to manufacturers, perhaps even offering better functionality and flavor. One of the problems though, is that …
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Seafood consumption is going up around the world, including in the US, with salmon being the fish species Americans love to eat the most. (The only seafood Americans eat more is shrimp, who of course are crustaceans, not fish.) The biggest wave of alt-meat so far has focused on beef replacement like burgers and sausages, given how many consumers al…
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Not everyone gets a second chance of life. But Inna Braverman got just that, and is using her second chance to try to solve one of humanity’s most pressing problems. Born in Chernobyl, Ukraine, Inna was only two weeks old when the nuclear disaster nearly took her life. When her mom found Inna blue and unresponsive from the pollution spewed from the…
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Imagine thinking it would be a good idea to try to help people eat more fruits and vegetables, so you start making whole foods smoothies for your friends and family. Soon you’re selling them to more people than you personally know. Next thing you know, you’re running an all-vegan frozen meal company with hundreds of millions of dollars in revenue, …
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If America’s roughly 180 million meat-loving dogs and cats formed their own nation, they’d reportedly be the fifth biggest meat-consuming country in the world. As pet-keeping has exploded in the developed world, so too has demand for all the chickens, fish, pigs, and cows to feed those pets. There’s even been a trend toward human-grade meat in pet …
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Maisie Ganzler has never worked at an animal welfare charity nor an alt-protein company. Yet she’s in the upper echelon of effectiveness when it comes to reducing the suffering of farmed animals. That’s because she’s served as an executive of a national food management company supplying 1,000 schools and corporate dining facilities, Bon Appetit Man…
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Many listeners of this show will be familiar with precision fermentation, or turning microbes into factories to produce proteins like those proteins that have historically been produced inside of chickens and cows. Think of companies whose founders we’ve had on, like Perfect Day and The Every Company. But, what if instead of using microbes as prote…
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Upon reading his obituary, Mark Twain reportedly wrote that “the reports of my death are greatly exaggerated.” Whether Twain actually wrote this or not, the reality remains that today the reports of the death of cultivated meat are indeed quite real. Yet Bruce Friedrich, the president of the Good Food Institute, is here to tell you that he believes…
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If you follow the cultivated meat sector, you know that the last couple years have been tough. Some companies have gone under, others have gone into hibernation, and others have shed staff in cash-conserving layoffs. Major publications have published opinion column obituaries for this industry, yet the work goes on. Part of that work is that of Obi…
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No cultivated meat company has raised more capital than UPSIDE Foods. In 2022, after having already raised about $200 million in previous rounds, the company raised another $400 million in a Series C round with a company valuation north of the coveted $1 billion unicorn status. No company in the space has garnered more media attention, both positiv…
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Asia is leading the world when it comes to semiconductors, solar panels, wind turbines, and other technologies critical for the future. In a time when several US states are seeking to ban the sale of cultivated meat, Asia seems to be leaning into the technology, and one of the most mature companies in the space there is Avant Meats. Founded in Hong…
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BlueNalu is one of the better-funded companies when it comes to cultivated meat. Having raised more than $100 million, including about $35 million toward the end of 2023—a notoriously difficult time to fundraise—their founder and CEO Lou Cooperhouse is optimistic about their path to success. But as you’ll hear in this episode, Lou isn’t working to …
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When you think about cultivated meat, Thailand isn’t exactly the first country that comes to mind. Sure, you may think about the US, Netherlands, Israel, and Singapore. But the Southeast Asian kingdom is where Israeli cultivated meat juggernaut Aleph Farms recently announced its first commercial factory will be. Having just received Israel’s first …
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When the New York Times recently ran an opinion column declaring the infant fatality of the cultivated meat industry, Isha Datar, CEO of New Harvest, was quoted as saying of the sector, “this is a bubble that is going to pop.” Given that New Harvest is intended to promote and advance the field, what did Isha mean by this? She expounded on that thou…
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In 2013, Dr. Mark Post shocked the world when he debuted the world’s first-ever burger grown from animal cells. Weighing in as a quarter-pounder, the burger carried a price tag of a mere $330,000—all of which was funded by Google co-founder Sergey Brin. A decade later, what does Mark think about the movement and the industry he helped birth? When h…
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Some of the companies in the cultivated meat space are betting that massive stainless steel cultivators—think 100,000L to 250,000L—are the path to commercialization. Niya Gupta, CEO of Fork and Good, is thinking smaller. She argues that there may be a more realistic path using a larger number of smaller tanks, void of the impellers that agitate the…
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If you listened to the last episode, you already know that there’s an updated paperback edition of my book Clean Meat that’s coming out April 9, 2024. I announced in that episode that, aligning with that release, this show will be devoted for a couple months exclusively to interviews with leaders in the cultivated meat space, many of whom are profi…
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I’m excited to announce in this short new podcast episode that there’s a new, updated, paperback edition of my book Clean Meat that’s coming out on April 9, 2024. Published by Simon and Schuster’s Gallery Books, the new Clean Meat is now available for preorder everywhere books are sold. Aligning with this new edition release, for the next couple mo…
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If you’ve spent any time in the startup ecosystem, you start realizing pretty quickly that the US isn’t alone in producing a lot of startups, but that there are some very small countries, like Israel and Singapore, that consistently punch above their weight when it comes to new company creation. In fact, Israel is often known as the startup nation,…
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Most startups are founded by entrepreneurs hopeful that their idea will be the next big thing and pad their bank accounts in the process. Yet sometimes companies are started not by enterprising capitalists, but rather by a far less likely progenitor: nonprofit charities. That’s exactly what happened when the nonprofit National Wildlife Federation d…
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Many times when we talk about technology that can improve animal welfare, we’re talking about innovations that either have displaced or could displace the use of animals. Think for example about cars replacing horse-power, kerosene replacing whale oil, and animal-free meats displacing factory farming of animals. But can technology also be used to m…
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Predictions abound for industries that allegedly will be upended by artificial intelligence, or AI. Will Uber drivers and truck drivers be replaced by AI-powered self-driving vehicles? Will writers and journalists be displaced by ChatGPT and its competitors? While many of our physical tasks have now been replaced by machines, it’s possible that in …
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As a young man, GW Chew saw his family dying early of lifestyle-related diseases, and he thought maybe he could do something about it. With a last name like that—yes, “Chew” is his real last name—maybe GW was destined to become a chef—that’s exactly what he did. Because of his interest in Seventh Day Adventism, GW gradually became Chef Chew by expe…
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Did you know that nearly half of all pregnancies in America are unintended? And that percentage skyrockets when we’re talking about teen pregnancies, more than three-quarters of which are unintended. While teen pregnancies and teen births are thankfully at an all-time low in the US, we’re still behind countries like the UK and Canada in this regard…
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Every time you take a step, you’re creating energy. Sadly, that energy isn’t captured and used to power your daily life. But what if it could be? That’s exactly what Pavegen is doing. What started as a guy tinkering in his room to make tiles that generate electricity when depressed is now a multimillion dollar startup with flooring installations in…
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You probably already know why coral reefs are so important—after all, they’re home to a quarter of all marine life. But do you know about seagrass? Seagrass not only provides habitat for aquatic wildlife, but it accounts for 10% of oceanic carbon storage, despite only taking up less than one percent of the seafloor. It also produces oxygen, cleans …
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Maxime Sigouin was on the verge of homelessness, surviving on free meals from his local food bank. After getting laid off from work and having only about $30 in his bank account, Maxime struggled to figure out how he could afford to survive, let alone try to help his partner as she endured her own mentally and financially taxing fight with cancer. …
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Did you know that nearly 10 percent of all CO2 emissions come from the creation of cement alone? That’s more than from all aviation! We rarely think about cement despite the fact that our society would literally collapse without it. Roads, bridges, buildings, and more all depend on this material that’s so ubiquitous we barely even notice it. In fac…
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Nearly all startups fail. Often even founders with a successful exit under their belts have stories of entrepreneurial strikeouts prior to or after their home run. But every once in while there’s a founder who seems to have the Midas touch who just keeps winning. No, I’m not talking here about Elon Musk. Rather, I’m talking about Yves Potvin. The c…
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A big part of what keeps you alive—among other things—is nitrogen. The plants you eat need it to grow, so for centuries farmers have been applying it to soil to make their acreage more productive. Prior to the 20th century, nitrogen fertilizer used to come from animal feces, blood, and bones—which is still common in organic agriculture today—but mo…
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