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“Research Ethics Reimagined” is a podcast created by Public Responsibility in Medicine and Research (PRIM&R), hosted by Ivy R. Tillman, PRIM&R's executive director. Here, we talk with scientists, researchers, bioethicists and some of the leading minds exploring new frontiers of science. This season, we are going examine research ethics in the 21st century -- and learn why it matters to you.
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Take your skills to the next level! Learning Life talks to experts with the newest ideas and valuable insight to help you improve your business and your brain. Elevate your team and your work. Learning is as easy as tuning in.
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High Fidelity

Bridget Conry

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A show exploring the intersection of cannabis, integrative selfcare and the arts. Hosted by Bridget Conry, an herbalist, foodie, art-lover and cannabis entrepreneur based in Burlington, VT. Tune in for quick hits on the emerging Vermont cannabis marketplace, pro tips on how to incorporate cannabis into a healthy lifestyle and engaging conversations with members of the cannabis community; no hate in this space, just High Fidelity.
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Entrepreneur, mother, and cofounder of Mamava—the inventor of the freestanding lactation pod—Sascha Mayer introduces her newest baby: The Bodacious Optimist, a podcast dedicated to celebrating and learning from the people who have inspired and supported her entrepreneurial journey. They are designers and storytellers, business leaders and activists who have challenged the status quo and thrived. Bodacious Optimists believe that there are always solutions waiting to be unveiled.
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Join couple-preneur Ruth and Brian Steinmetz as they share their expertise in real estate, design and social activism. As co-founders of “Steinmetz”, a real estate brokerage and interior design firm serving mainly Chittenden County, Vermont, they explore the intersection of wellness and the art of conscious dwelling through what they call dwellness. They’ll cover topics like equity- in all its forms, environmental and social justice, conscious consumption, mental and community health and so ...
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News for the week of November 17, 2025: Angular 21 is zoneless by default and adds Vitest support, plus Shai-Hulud worm hits another 500+ npm packages. What's a dev to do??? From the community: you basically know C# if you already know TypeScript and a new decorator-free dependency injection library inspired by Autofac. Sponsored by Excalibur.js Ex…
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In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we celebrate PRIMR25 Award recipients Lisa Chuba and Alison Pohl from UConn Health, along with the first-ever Outstanding Student Poster Award recipient, Leah Huff, from the University of Virginia. Chuba and Pohl discuss transforming their IACUC's relationship with researchers from …
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News for the week of November 10, 2025: Node 25 marks type stripping as stable, the downlow on some new Rust-based JavaScript and TypeScript engines, and a new browser for keyboard lovers. From the community: visualize how types work, using .NET Aspire without .NET, type-safe SQL, and an experimental Rust-based type checker. Sponsored by Excalibur.…
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Daniel Rosenwasser and Jake Bailey join the two fools to talk about what's coming soon in TypeScript 6 and 7. What changes should developers expect? What might the new compiler API look like? How is the Go port progressing? We talk about smarter (and stricter) defaults, ES targets, module resolution, and why it's hard to emulate JavaScript floating…
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News for the week of November 3, 2025: Node 24 promoted to LTS, Nuxt Image V2 is full of TS goodies, and Anders is humbled by TypeScript's rise. From the community: TypeScript is not a substitute for good engineering, why codemods are helpful, and examples of using the satisfies keyword. Chapters (00:00) - Welcome to the Show (05:24) - Announcement…
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News for the week of October 27, 2025: TypeScript is the #1 language on GitHub, making your Regex type-safe, and Biome adds support for three new metaframeworks. From the community: a metaframework for Angular, PHP in JS, and a polyglot runtime that will blow your mind. Chapters (00:00) - Welcome to the Show (05:36) - News: TypeScript Won in 2025 (…
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In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we speak with Dr. Josh Fessel about trust in science, translational medicine, and the challenges facing federal research. Dr. Fessel is a physician scientist who most recently served as chief medical officer and director of the Office of Translational Medicine in the National Center…
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News for the week of October 20, 2025: Deno Deploy revamp, Vitest 4, Nuxt 4.2, and Next.js 16, all in a single week. From the community: 4 weird ways to cast in TypeScript (+2 to Arcana rolls), type-safe API clients, and the hottest JS REPL around. Chapters (00:00) - Welcome to the Show (05:04) - News: Deno Deployed a Brand Spankin' New Deno Deploy…
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News of the week of October 13, 2025: Node 25 brings V8 perf update, Remix reinvents itself once again, TypeScript in your DB, and why Map upsertions will be celebrated by TS devs. From the community: 15 npm packages you no longer need, Deno's side projects, Snoop L. O. Double G., and how to write architecture assertions. Chapters (00:00) - Welcome…
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News of the week of October 6, 2025: Highlights from ReactConf 2025, Bun 1.3's (delicious) security lede got buried, and how to buy lifetime access to someone's webcam for $500. From the community: CSS is cool again, Immer.js perf improvements, and why typed linting is blocked by ESLint core. Chapters (00:00) - Welcome to the Show (05:52) - News: R…
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News of the week of September 29, 2025: Is Deno the answer to npm's security issues? From the community: replacing .env files with 1Password, stepping outside of TypeScript's padded room, and temporal dead zones. Plus, Kamran fell into a rabbit hole and defeated the Red Queen: SSR with .NET. Chapters (00:00) - Welcome to the Show (07:39) - News: TS…
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News of the week of September 22, 2025: new default option in TS 6.0, Jiti upgrade, and Cloudflare's on a tear. Plus, npm's security roadmap. From the community: Python-style kwargs, running TS on MS-DOS, and running JS on PlayStation. Chapters (00:00) - Welcome to the Show (07:42) - News: Take the State of JS Survey 2025 (08:25) - News: TS 6.0 Wil…
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News of the week of September 15, 2025: Shai-Hulud worm hits npm supply chain, WebAssembly 3 spec is ratified, and Elixir fans finally get their time in the spotlight. From the community: SquiggleConf was awesome, type branding and tuples, local-first app dev, and why @ts-ignore is almost always the worst option. Chapters (00:00) - Welcome to the S…
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In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we explore the intersection of artificial intelligence, trust, and bioethics with Dr. Vardit Ravitsky, President and CEO of the Hastings Center for Bioethics. Dr. Ravitsky discusses the rapid implementation of AI in healthcare and biomedical research, strategies for combating misinf…
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David Blass (@ssalbdivad.dev) teaches the two fools about ArkType and its 1:1 validator type system. If you, like us, thought ArkType was only about validation, think again! David pulls back the curtain on what makes ArkType unique, how he built a type-level parser to provide helpful error messages, and why ArkType can provide soundness guarantees …
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In this episode of the Bodacious Optimist podcast, host Sascha Mayer talks with Noah Miller, a leader in Environmental and Social Governance (ESG). The discussion delves deep into the definition and importance of ESG pillars: environmental stewardship, social impact, and governance. Noah recounts his unique career path, including his time as a prof…
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News of the week of September 8, 2025: Deno 2.5 adds a bunch of DX improvements, Fresh 2.0 is out of beta, and a supply chain attack mitigation for pnpm users. From the community: Val Town's OSS TypeScript editor, discussing underrated TS features, and tools/libraries to help make your configs, secrets, and forms type-safe. Chapters (00:00) - Welco…
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News of the week of September 1, 2025: Deno Fresh 2.0 is now in beta, Swift 6.2 adds WASM support, and a serious spear-phishing attack on npm maintainers. From the community: looking back on TypeScript, optimizing immutability, type-safe state machines, sharing Wi-Fi links, and some prolific open source work. Chapters (00:00) - Welcome to the Show …
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News of the week of August 25, 2025: the two fools unpack the expected breaking changes to TSConfig in the upcoming 6.0 release, explain Node's latest LTS notable changes, and cover the latest in the JS trademark case from Deno. Plus, a PSA if you use Nx! From the community: making the case to migrate to Node's type stripping, a peek at Vitest 4, Z…
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In this episode of "Research Ethics Reimagined," we explore human challenge studies for shigellosis, examining their role in vaccine development and the ethical considerations surrounding intentional infection of healthy volunteers. Our guests are Dr. Wilbur H. Chen, the Frank M. Calia, MD Endowed Professor and Chief of the Division of Geographic M…
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News of the week of August 18, 2025: one of the biggest nightly updates for TS Go, Rspack team announces a new linter, the new minor Bun release is pretty major, and Next.js 15.5 features typed routing . From the community: more learning web dev resources, an exhaustive switch utility for JSX, --strict on by default?, and whether you can really pro…
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News of the week of August 11, 2025: there ain't much! Astro 5.13 minor release brings enums to Astro DB and improved meta environment variables. From the community: learning web dev, Result-typing Next.js server actions, and Clickhouse built an ORM. Chapters (00:00) - Welcome to the Show (05:07) - News: Astro 5.13 Adds import.meta.env and Astro DB…
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In this episode of the Bodacious Optimist podcast, Sascha interviews Dr. Lisa Stellwagen, a pediatrician and leading advocate for breastfeeding and milk banking. Dr. Stellwagen, who played a key role in establishing UC San Diego's baby-friendly hospital designation and cofounded the UC Health Milk Bank, discusses the importance of milk banks in pro…
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News of the week of August 4, 2025: WebStorm 2025.2 adds support for TypeScript Go language server (preview), V8 made JSON.stringify supa-supa-fast, and there's a new TypeScript AI conference on the block. From the community: recommended tools and libraries for TS developers, how to prevent ReDOS attacks, and an interview discussing how the JavaScr…
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Joshua Goldberg (JoshuaKGoldberg.com), creator of typescript-eslint, joins us to discuss the state of linting TypeScript projects in 2025. Which linters should we pay attention to? Why are there so many? What's unique about TypeScript? Josh shares his perspective and covers what to look for in a linter and how best to utilize them in your projects.…
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News of the week of July 28, 2025: TS 5.9 released, Node 22.18 is the first LTS to support TypeScript, a Rust-based alternative to Next.js, plus why Laravel ain't your pappy's PHP. From the community: eslint-max-depth-ts plugin, Zod vs. Valibot battle, Better Auth is so good, a deal with the TypeScript devil, and did you know you can render motion …
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Liran Tal (lirantal.com) from Snyk joins us to dive deep into writing secure TypeScript applications. What's different compared to vanilla JavaScript security? Will schema validators fix all our woes? Can't we let LLMs find and fix security vulnerabilities? Liran educates us about the pitfalls and risks with misplacing trust in TypeScript and LLMs …
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In this episode of PRIM&R's podcast, "Research Ethics Reimagined," we explore groundbreaking cancer vaccine research for dogs with potential implications for human cancer treatment. Our guest is Dr. Mark Mamula, Professor at the Yale School of Medicine and leading researcher in immunology and innovative vaccine development.…
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News of the week of July 21, 2025: Deno Fresh 2.0 is in alpha, TS 5.9 RC has some small changes, and beware the latest eslint-config-prettier supply chain attack. From the community: learn TypeScript for free in an hour, master generics through Soduku, run TS in the browser without a build step, and a library for modern TS dependency injection. Cha…
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In this episode of the Bodacious Optimist podcast, the host interviews Tricia Johnson, a professor at Rush University's Department of Health Systems Management. As a human milk economist, Tricia discusses her work in understanding the economic drivers of healthcare spending, particularly focusing on the cost-effectiveness of feeding mother's own mi…
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News of the week of July 14, 2025: Nuxt 4.0 is released along with an acquisition by Vercel, TSGO ships go-to-type definition support, and Bun ships smarter types. From the community: test type completions and benchmark instantiations with a testing package from Arktype, treating types as values with type-level maps, and dive a bit deeper into how …
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News of the week of July 7, 2025: We dive into the TypeScript 5.9 beta, an experimental Go linter for TS/JS, plus make sure you upgrade your Node.js versions! From the community: a new enum syntax proposal in case JS doesn't get native enums, TSL brings faster type-aware linting, and trashh_dev asks TypeScript: WTF? Chapters (00:00) - Introduction …
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News of the week of June 30, 2025, Deno Bundle is Back in Black in 2.4! We coin the term "Bweet", Deno also gets some non-standard import attributes for text and bytes, OTEL is now stable in Deno, and Next.js has a DoS vulnerability. From the community: we chat about modern Node.js patterns for 2025, NDC Oslo talks are rolling in on YouTube, and st…
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News for the week of June 23, 2025: Ecma ratifies ES2025 standard, Vite 7 is mostly deprecations, Oracle gets a free pass, and the experimental type stripping warning is... stripped... from latest Node LTS releases. From the community: 6 advanced TS tricks, a new type-safe WebSockets API, and RegEx tips. Chapters (00:00) - Introduction and Personal…
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News for the week of June 16, 2025: Biome v2 features type-aware linting without TSC, Mocha and Jest both get native ESM and TS upgrades, and Grafana Lab's k6 load testing tool... also can now run native TS tests. From the community: type safety for WebGPU shaders, type narrowing map and indexed key access, and resilient import maps. Chapters (00:0…
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News for the week of June 9, 2025: Node's type stripping wrapper is released as a standalone package, VoidZero is building a super fast linter, and pnpm introduces experimental virtual store for speeding up package installs. From the community: secure your TS apps, #ROLP, and updated Exploring JS book edition for 2025. Chapters (00:00) - Introducti…
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In this episode of the Bodacious Optimist podcast, host Sascha Mayer interviews Corinne Botz, a visual artist and educator whose multidisciplinary work spans photography, writing, and filmmaking. The conversation centers around Botz’s project, “Milk Factory,” which includes a short film and a book about lactation rooms. Botz shares how the origins …
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News for the week of June 2, 2025: TSC init command gets new, modern defaults, plus new betas drop for Vite 7 and Babel 8. From the community: Learn advanced TS features in 25 mins, and improve the performance of your TS monorepos with secret arcane knowledge. Chapters (00:00) - Introduction and Personal Updates (02:26) - News: tsc --init Finally H…
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In this episode of "Research Ethics Reimagined," Mark Barnes, JD, LLM, a partner in the healthcare and life sciences practice at Ropes and Gray LLP in Boston shares his thoughts on the first 100 days of the new administration and identifies the ongoing legal challenges that affect the research oversight community.…
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Jason Yu (ycmjason.codes) joins us to share an open source tool he created to help teams migrate their legacy TSConfig compiler options to modern-day options painlessly and progressively. Learn about his experience implementing strict options on big teams, how it inspired his new tool, and how you can take advantage of it right now! Chapters (00:00…
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News for the week of May 26, 2025: Angular's 20th release brings DX improvements, Remix replaced by React Router receives reincarnation, and how a lone volunteer brings the much-anticipated Temporal API to Firefox. Chapters (00:00) - Personal News and Updates (04:46) - News: Angular 20 is Out and It's Boring (But in a Good Way) (08:39) - News: Remi…
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News for the week of May 19, 2025: Try out the new TypeScript Go native port, Zod 4 is out, and no, Deno is not dead. Chapters (00:00) - Introduction and Personal News (05:12) - News: TypeScript Native is in Preview! (10:12) - News: Anders' Talk About TS Native at MS Build (12:58) - News: Zod 4 is Officially Released (15:51) - News: Reports of Deno…
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News for the week of May 12, 2025: Microsoft layoffs impact TypeScript team, and Deno explains the radio silence on Fresh 2.0. Chapters (00:00) - Personal News (06:25) - Correction: Node 24's Security Model (07:22) - News: Microsoft Lay-offs Impacting TypeScript Team (11:32) - News: Deno Posts an Update on Fresh 2.0 (13:27) - News: TSGo Gets LSP Co…
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In this week's deep dive, we cover everything TypeScript developers need to know about the latest Node 24 release, including examples of each new language feature. We've even put together a code snippet repo you can check out! Chapters (00:00) - Introduction to Node 24 and TypeScript Support (02:49) - Type Stripping and Experimental Transform Types…
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News for the week of May 5, 2025: Node 24 officially brings TS support to the masses, Parcel adds RSC support, and a TC39 proposal gets replaced. Chapters (00:00) - Introduction (04:07) - News: Node 24 Release Highlights (08:09) - News: What's New in TSGo? (09:05) - News: TC39 Records and Tuples Proposal Has Been Withdrawn (11:45) - News: Parcel Bu…
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News for the week of April 28, 2025: Deno 2.3 brings some nice quality-of-life improvements, plus void(0) has released a new all-in-one bundler for your TypeScript libraries. Chapters (00:00) - Introduction (04:51) - News: This Week in TypeScript Go (05:47) - News: Deno 2.3 Released (08:36) - News: tsdown is a TypeScript Bundler for Library Authors…
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Erik shares how you can build games for the web with TypeScript and the Excalibur.js game engine. What's involved? What are some of the primitives you need to learn? What tools are there to make assets? And how do your webdev skills translate? All this and more in today's deep dive episode! Chapters (00:00) - Introduction to Excalibur.js (01:13) - …
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In this episode of "Research Ethics Reimagined," we explore community-engaged research and its role in advancing health equity, particularly in cancer care. Our guest is Monica L. Albertie, Director of Research Operations for Community Outreach and Engagement at the Mayo Clinic Comprehensive Cancer Center. She provides operational leadership for ca…
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News for the week of April 21, 2025: TSGo gets autocomplete and JSX support, pnpm adds JSR support, and remember to migrate off Node 18! (00:00) - Introduction and Personal Updates (04:55) - News for the Week of April 21, 2025 (06:26) - News: TSGo Gets JSX and Autocomplete Support (08:36) - News: pnpm Gets JSR Package Support (10:00) - News: Juno A…
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In this episode, Erik and Kamran have a candid discussion about how the podcast started, how it went, and what the plans are for the future. Chapters (00:00) Introduction (01:18) Is TypeScript.fm Done? (01:59) Erik's Reflection (03:05) Kamran's Reflection (03:48) What's the Goal of the Podcast? (06:46) What Do We Want to Focus On? (12:10) Should We…
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