Best Technology That Gives You Superpowers Podcasts (2025)

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Tom Neyarapally, Archetype Therapeutics | A new paradigm for generative AI drug discovery: more accurate shots on a much wider goal | TPM podcast #47 42:43

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7h ago42:43

42:43

Joining us on this episode is Tom Neyarapally, co-founder and CEO of Archetype Therapeutics, an exciting new AI-driven company in the drug discovery space. Archetype is an AI-native biotech pioneering the use of generative chemogenomics and patient clinicogenomic data to virtually screen billions of potential drug candidates each day. ⁠⁠TPM E47 hig…

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‘The Next Big Idea Daily’: How to Raise Great Kids in a Messed-Up World 14:21

13h ago14:21

14:21

Science journalist Melinda Wenner Moyer, shares research-backed strategies for parenting with compassion, curiosity, and resilience from her new book, Hello, Cruel World!: Science-Based Strategies for Raising Terrific Kids in Terrifying Times. 📱 Follow The Next Big Idea Daily on Apple Podcasts, Spotify, or wherever you listen 📩 Want more bite-sized…

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Best Of: Michael Lewis Runs Toward Pleasure 1:11:58

5d ago1:11:58

1:11:58

This is one of our favorite conversations from the last year. On the surface, it's an interview we did with Michael Lewis to coincide with the paperback release of Going Infinite, his book about Sam Bankman-Fried and the collapse of FTX. Michael, who spent months hovering over Sam's shoulder, believes he wasn't some malevolent grifter: he was an aw…

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How Susan Cain Found Her Voice 45:23

12d ago45:23

45:23

Susan Cain always knew she wanted to be a writer. But her path to becoming one was anything but straightforward. She took a creative writing class in college and came away convinced she wasn’t very talented. So she pivoted: law school, white-shoe firm, eyes set on making partner. Seven years later, a senior partner walked into her office with life-…

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HOPE FOR CYNICS: The Surprising Science of Human Goodness 58:06

20d ago58:06

58:06

We think that cynicism protects us from being disappointed by other people. But Stanford psychologist Jamil Zaki says the opposite is true. When we expect the worst in people, we create a self-fulfilling prophecy that brings out exactly what we feared. So in his new book, Hope for Cynics, Jamil sets out to prove that hope isn't naive: it's smart. 🎁…

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RISE ABOVE: How to Realize Your Full Potential 45:36

26d ago45:36

45:36

Psychologist Scott Barry Kaufman broke free from resentment and rumination, shifting into what he calls an empowerment mindset. Are you ready to do the same? • Support our show by becoming a Next Big Idea Club member. Learn more hereBy Next Big Idea Club

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MORAL AMBITION: Are You Wasting Your Talent? 1:20:48

1M ago1:20:48

1:20:48

What if everything we've been told about having a successful career is wrong? Rutger Bregman thinks most of us are wasting our working lives and argues we should stop trying to get rich and start trying to solve the world's problems instead.By Next Big Idea Club

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Stéphane Budel, DeciBio | Precision medicine is our future and our fate | TPM podcast #46 50:02

1M ago50:02

50:02

Stéphane Budel, founding partner at DeciBio, joins the Talking Precision Medicine Podcast to explore the future of the field. He unpacks how liquid biopsy, multi-omics, and AI are opening new doors for personalized care, why the diagnostics business model is holding innovation back, and what it will take to make complex tech usable for clinicians a…

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NVIDIA: Jensen Huang Bet Big on AI. What Comes Next? 1:21:51

1M ago1:21:51

1:21:51

In his new book, The Thinking Machine, Stephen Witt offers a riveting portrait of Jensen Huang, who went from immigrant dishwasher to CEO of the world’s most valuable company. • If you enjoyed this episode, check out our conversation with Walter Isaacson about his biography of Elon MuskBy Next Big Idea Club

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EXPLORATION: Why We Seek Out Big Challenges 53:06

2M ago53:06

53:06

Humans are wired to explore. So why are we less adventurous than ever — and what are we losing because of it? Guest: Alex Hutchinson, author of The Explorer’s Gene Further Listening: Looking for more episodes about adventure? Check out our conversations with Colin O’Brady and David GrannBy Next Big Idea Club

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AI 2027: What If Superhuman AI Is Right Around the Corner? 1:37:07

2M ago1:37:07

1:37:07

Could AI take over in the next few years? Daniel Kokotajlo thinks so. Here’s why. 💿 Check out this Spotify playlist of our other episodes about AI 📩 Want to transform your day in just 10 minutes? Sign up for our Book of the Day newsletter, and you’ll get daily, bite‑sized insights from the best new nonfiction books — in audio or text — straight fro…

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THE ART OF EDITING: Graydon Carter on the Golden Age of Magazines 59:38

2M ago59:38

59:38

Remember magazines? Piled high on coffee tables or tucked into seatback pockets. Savored beneath beach umbrellas or skimmed anxiously in dental waiting rooms. Glorious, glossy magazines. Graydon Carter made some of the best. He started with Spy, a sly, sharp-edged monthly that managed to feel both smarter and more mischievous than anything else on …

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Anna Berkenblit & Sudheer Doss, PanCAN | On a mission to beat an ignoble killer: pancreatic cancer | TPM podcast #45 46:10

2M ago46:10

46:10

Today’s guests are Anna Berkenblit, Chief Scientific and Medical Officer at the Pancreatic Cancer Action Network, and Sudheer Doss, Chief Business Officer at PanCAN. The Pancreatic Cancer Action Network is the leading organization dedicated to advancing progress against pancreatic cancer. It empowers patients and caregivers, drives early detection …

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FAMILY DYNAMICS: Unraveling the Mystery of Sibling Success 52:51

2M ago52:51

52:51

You know those families where the kids all grow up to be remarkably successful? New York Times journalist Susan Dominus has spent the last few years getting to know some of them, looking for parenting techniques and life lessons. She's written a book about her findings called The Family Dynamic. "I thought I wrote a book about high-achieving famili…

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ABUNDANCE: Derek Thompson on How to Actually Rebuild the American Dream 1:13:16

3M ago1:13:16

1:13:16

Abundance by Ezra Klein and Derek Thompson is probably the most talked-about book in the country right now. And the most hotly debated. It’s a book about how we got here — here being a country without enough housing, a country that has lost its ambitious optimism, a country that has forgotten how to build. The prescription Ezra and Derek offer to c…

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WHY GIVERS WIN: Adam Grant Revisits 'Give and Take' 1:08:39

3M ago1:08:39

1:08:39

We’re often told that success comes down to talent, hard work, and luck. But Adam Grant's research suggests that view is missing something crucial. In today’s installment of Next Big Idea Classics, Adam revisits his 2013 bestseller “Give and Take,” explaining how our interactions with others determine who thrives and who doesn’t. 💿 For Adam’s previ…

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Najat Khan | Radical Transformation: Becoming a Medicines Company with End-to-End AI | TPM #44 38:35

3M ago38:35

38:35

Today’s guest is Najat Khan, Chief R&D Officer and Chief Commercial Officer at Recursion Pharmaceuticals. Recursion is widely recognized as one of the most visible—and so far, most successful—companies to emerge from the tech-bio movement. Many consider it the current industry leader. It has become an iconic name in the field of artificial intellig…

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BITCOIN: A 15-Year Quest to Unmask the Mysterious Inventor of Crypto 58:20

3M ago58:20

58:20

In 2008, a mysterious figure created Bitcoin — a digital currency without banks or borders that sparked a global financial movement. And then he disappeared without a trace. Who is Satoshi Nakamoto? Why did he vanish? And why hasn’t he touched his $100 billion fortune? Today on the show, we talk to journalist Ben Wallace about his search for answer…

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YOU, BUT BETTER: The Science and Promise of Personality Change 51:25

3M ago51:25

51:25

Can you change who you are? When reporter Olga Khazan decided she was tired of being a “high-strung misanthrope” (her words), she turned to science for answers. What she discovered about personality — and how to change it — might surprise you. Host: Daniel Pink Guest: Olga Khazan Book: Me, But Better This episode was recorded live at Politics and P…

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CARL ZIMMER: The Untold Story of the Air We Breathe 56:31

3M ago56:31

56:31

Every day you inhale 2,000 gallons of air. What’s in there? 📕 Air-Borne: The Hidden History of the Life We Breathe by Carl Zimmer 📩 Want to transform your day in just 10 minutes? Sign up for our Book of the Day newsletter, and you’ll get daily, bite‑sized insights from the best new nonfiction books — in audio or text — straight from the authors. Si…

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SAHIL BLOOM: The 5 Types of Wealth 1:05:50

4M ago1:05:50

1:05:50

Turns out it’s not all about the Benjamins. Real success, according to Sahil Bloom, author of “The 5 Types of Wealth,” also requires the freedom to decide how you spend your time, meaningful relationships, a sense of purpose that pulls you forward, and the kind of health that lets you actually enjoy all of the above. 📩 Want to transform your day in…

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STORY: How to Tell a Great One (Part 2) 45:56

4M ago45:56

45:56

In part two of our conversation with Will Storr about his new book A Story Is a Deal, he reveals the five storytelling techniques you can use to captivate any audience. Plus, he helps us craft the story of the Next Big Idea Club. 1️⃣ Listen to Part 1 here 📩 Want to transform your day in just 10 minutes? Sign up for our Book of the Day newsletter, a…

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Ryan Fukushima | Reinventing diagnostics: The superpower of not knowing what can’t be done | TPM #43 43:19

4M ago43:19

43:19

What a pleasure to welcome today’s guest, Ryan Fukushima, chief operating officer of TempusAI. Not only has Ryan helped build Tempus brick by brick from the earliest days, he is also CEO of Pathos AI, a biotech company using real world data and AI to develop true precision medicines. I don’t know how he juggles it all, but unless you’ve been hiding…

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STORY: The Science Behind Humanity’s Superpower (Part 1) 54:54

4M ago54:54

54:54

Today, we’re sitting down with Will Storr, author of the dazzling new book A Story Is a Deal, to talk about humanity’s greatest invention: story. More than just entertainment, Will argues, story is what we do and who we are. It’s how we make sense of the world, captivate, and persuade. And yet for all its power, storytelling isn’t some elusive magi…

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The Former Head of USAID on Why Foreign Aid Benefits Everyone 52:22

4M ago52:22

52:22

When Rajiv Shah was in his late 20s and didn’t know what to do with his life, he got a job at a fledgling nonprofit, the Bill and Melinda Gates Foundation. Before he knew it, he was a driving force behind a global vaccination program that immunized 900 million children and saved 16 million lives. At 36, he became the administrator of the United Sta…

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Three Things We Learned Last Year 37:14

5M ago37:14

37:14

In this special audio essay, Rufus reflects on the big ideas from 2024 that altered his worldview. 🎙️ You can find all of the interviews mentioned in this episode in this Spotify playlist 📩 Want to transform your day in just 10 minutes? Subscribe to our Book of the Day newsletter, and you’ll get daily, bite‑sized insights from the best new nonficti…

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The journey to the top of life sciences technology: a lifetime of listening and learning | Talking Precision Medicine #42 47:34

5M ago47:34

47:34

Today my guest is Joydeep Goswami, newly appointed President and CEO of the storied biotechnology company LGC. Joydeep is also a strategy advisor to Genialis. Join us as we discuss his remarkable career and lessons learned at each step of the way. Come on in and have a listen. Episode 42 links: ⁠⁠⁠⁠⁠⁠⁠TPM E42⁠⁠⁠ for highlights and links from this e…

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SUPERAGENCY: What Could Go Right With AI? 1:01:29

5M ago1:01:29

1:01:29

A recent Pew Research survey found that most Americans are more worried than excited about AI. Reid Hoffman, however, isn't one of them. He knows the risks — arms races, runaway superintelligence, the whole humans-being-turned-into paperclips scenario — but he's still convinced that AI is poised to usher in an era of extraordinary human progress. A…

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SHIFT: How to Manage Your Emotions 1:08:15

5M ago1:08:15

1:08:15

We've got a special treat for you today. We invited Ethan Kross — psychologist, neuroscientist, and author of the bestseller "Chatter" — to give us a sneak peek at his new book, "Shift." It comes out in February, and it's a myth-busting, science-based guide to mastering your emotional life using tools you already possess. 📕 Pre-order Ethan's book h…

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WINTER: The Secret to Thriving in the Darkest Season 59:57

5M ago59:57

59:57

In our deeply divided nation, there's one thing many of us seem to agree on: winter is the worst. A recent study found that nearly half of Americans would skip winter if they could. Yet not everyone dreads the cold months. Psychologist Kari Leibowitz has spent years studying these winter-lovers, and she's arrived at a surprising truth: people who t…

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DRIVE: A Fresh Look at the Science of Motivation (with Daniel Pink) 1:11:47

6M ago1:11:47

1:11:47

What drives human motivation? For years, the answer seemed simple: rewards. Dangle the right carrot — a bonus, stock options, "Employee of the Month" certificate — and people will perform. But Daniel Pink's 2009 bestseller "Drive" flipped this idea on its head. Drawing on decades of scientific research, Dan revealed that our deepest motivations com…

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James Clear’s Ultimate Guide to Building Good Habits (Encore) 1:16:13

6M ago1:16:13

1:16:13

Forming a new habit is tough. Sticking with it is even tougher. That’s probably why someone buys a copy of James Clear’s 2018 book “Atomic Habits” every 11 seconds. James breaks down the science of habit formation into simple, actionable steps anyone can take — even you. Today on the show, he talks Rufus through the four laws of behavior change, ex…

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How to Find Purpose, Meaning, and Success (2022) 1:10:59

6M ago1:10:59

1:10:59

Arthur C. Brooks used to run a prominent think tank where he was paid handsomely to influence public policy. Did all that success make him happy? Nope. So Arthur quit his job and set out to transform his life. Now he’s written a book about what he learned along the way, the #1 New York Times bestseller “From Strength to Strength: Finding Success, H…

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WHAT IS LIFE? (Part 2): Consciousness, AI, and Aliens 59:09

6M ago59:09

59:09

Does free will exist on a sliding scale? Will humans and AI co-evolve? Are aliens already here on earth? These are just a few of the many mind-bending questions Rufus and Sara Walker, author of “Life as No One Knows It,” explore in the second half of their conversation. 1️⃣ If you missed the first half of Sara’s interview, you can find it here 🧪 Wa…

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The view from 30,000: Healthcare & life science AI in the cloud | Talking Precision Medicine #41 37:10

6M ago37:10

37:10

This episode features a conversation with Shweta Maniar, who leads the Healthcare and Life Science effort at Google cloud. In just a few short years, artificial intelligence has gone from the stuff of hype and fairy tale to powerful and ubiquitous tools for all aspects of R&D and healthcare delivery. Google has been central to this sea change. I di…

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WHAT IS LIFE? (Part 1): A Mind-Bending Conversation with Sara Walker 1:02:26

6M ago1:02:26

1:02:26

We’ve had many bracing thinkers on this show, but Sara Walker might take the cake. A physicist and astrobiologist at Arizona State University, she's just written "Life as No One Knows It: The Physics of Life's Emergence," a thrilling exploration of life's origins and the search for it across the cosmos. 🕐 The second part of this conversation will b…

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STRATEGY: How to Make Better Plans 1:01:47

6M ago1:01:47

1:01:47

You may think you know what strategy is, but Seth Godin is willing to bet you haven’t got a clue. It’s not just setting goals. It’s not just making plans. It’s— Well, you’ll have to tune in to find out. 📕 This Is Strategy by Seth Godin ✉️ Want big idea delivered to your inbox every day? Sign up for our newsletter Book of the Day here 🎙️ If you enjo…

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TECH AGNOSTIC: How Technology Became the World's Top Religion 53:59

7M ago53:59

53:59

Greg Epstein, the humanist chaplain at Harvard and MIT, wants you to think twice before putting your faith in Silicon Valley's promises. 🎙️ Follow The Next Big Idea Daily on Apple or Spotify 🎁 Take 20% off a Next Big Idea Club membership or gift when you use PODCAST20 at nextbigideaclub.comBy Next Big Idea Club

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The Remarkable Power of Giving People More Than They Expect (2023) 1:07:06

7M ago1:07:06

1:07:06

When he was 26, Will Guidara took the helm of a middling brasserie in New York City called Eleven Madison Park. A decade later, it was named the best restaurant in the world. How did he pull off this unprecedented transformation? By practicing unreasonable hospitality. (This episode first aired in Sept. 2023.) 📕 Unreasonable Hospitality 📬 Take 50% …

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CATCHING SOULS: An Obituary Writer’s Lessons for Living 53:55

7M ago53:55

53:55

For two decades, Ann Wroe has written weekly obituaries for The Economist. Some of her subjects are luminaries (Queen Elizabeth II, Paul Newman). Others are little-knowns (cheesemakers, storm chasers, typewriter repairmen). But all of them, in Ann’s words, “have enhanced the world by their existence.” Her obituaries are celebrations of life, and An…

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THE INTERESTING: How to Live the Good Life 1:04:35

7M ago1:04:35

1:04:35

Philosophers have long maintained that the Good Life is braided from two strands: pleasure and purpose. But Middlebury’s Lorraine Besser says there’s a third: psychological richness — or, as she calls it, The Interesting. Interesting experiences, she contends, captivate our minds, engage our thoughts and emotions, and often change our perspective. …

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What’s in a digital twin? Inventing new kinds of AI for biomedicine | Talking Precision Medicine #40 47:02

7M ago47:02

47:02

Our guest this episode is Charles Fisher, co-founder and currently Chief Scientific Officer of Unlearn.AI. Unlearn has been a leader in the advancement of Digital Twins as a tool to drastically improve the efficiency of clinical trials. Not only a visionary scientist and trailblazing entrepreneur, Charles is fearless with his hot takes. So sit back…

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A Productivity Podclass with Cal Newport 42:19

7M ago42:19

42:19

Do fewer things. Work at a natural pace. Obsess over quality. These are Cal Newport's three principles for achieving your goals without burning out. Today, in a special preview of our first-ever podclass, Cal explains how to harness the power of slow productivity to bring meaning, purpose, and a genuine sense of accomplishment into your life and wo…

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Human History Is Not Set In Stone 1:10:15

8M ago1:10:15

1:10:15

What if everything we think we know about the history of our species is wrong? That’s the provocative question at the heart of a new book by today’s guest, David Wengrow. Hailed as fascinating, brilliant, and potentially revolutionary, “The Dawn of Everything: A New History of Humanity” debuted at no. 2 on the New York Times bestseller list. Drawin…

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Want a More Meaningful Life? Embrace Your Limitations. 1:21:16

8M ago1:21:16

1:21:16

In his mega-bestseller “Four Thousand Weeks,” Oliver Burkeman showed that the shortness of life “isn’t a reason for unremitting despair, or for living in an anxiety-fueled panic about making the most of your limited time. It’s a cause for relief.” Now, in “Meditations for Mortals,” he invites us to embrace what he calls “imperfectionism.” Accept yo…

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THE WORK OF ART: How Something Comes From Nothing 56:41

8M ago56:41

56:41

Making art is hard work, as Adam Moss, the revered former editor of New York magazine, reveals in his illuminating new book, "The Work of Art." The book is a collection of interviews with painters, poets, filmmakers, and even sandcastle builders about the demanding, mystical, peculiar process of creating something out of nothing. Adam spoke with ou…

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ANXIOUS GENERATION (Part 2): How to Raise Resilient Kids in the Digital Age 36:50

8M ago36:50

36:50

Earlier this week, Jonathan Haidt joined us to discuss the crisis in youth mental health caused by smartphones and social media. Now he’s back to talk solutions. ✉️ We launched a Substack! Check it out now at bookoftheday.nextbigideaclub.com 🎙️ Enjoy this episode? Check out Rufus's related conversations with Will Storr and Anna Lembke…

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ANXIOUS GENERATION (Part 1): What Social Media Is Doing to Our Kids 54:39

8M ago54:39

54:39

It’s rare these days for a book to go viral, but that’s exactly what happened with “The Anxious Generation: How the Great Rewiring of Childhood Is Causing an Epidemic of Mental Illness” by Jonathan Haidt. Now in its seventh month on the New York Times bestseller list, the book shows how the mass adoption of smartphones and social media has led to r…

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Life Is a Game. Here's How to Play It. 1:31:20

9M ago1:31:20

1:31:20

“Life is a game. There’s no way to understand the human world without first understanding this. Everyone alive is playing a game whose hidden rules are built into us and that silently directs our thoughts, beliefs and actions. This game is inside us. It is us. We can’t help but play.” So begins The Status Game by acclaimed science writer Will Storr…

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Leave No Patient Behind—R&D Tools and Cutting Edge Diagnostics that Span the Globe | Talking Precision Medicine #39 35:38

9M ago35:38

35:38

What a genuine pleasure to sit with Thierry Bernard, CEO of Qiagen. As I told Thierry, Qiagen is a truly iconic brand for anyone who came up through molecular biology laboratories in the past 30 years. Their products were ubiquitous, and crucial, to the success of our research. In this conversation, Thierry talks about his global vision for precisi…