Best Aubrey de Grey Podcasts (2025)

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YC Biotech Founder Wants to End All Rare Disease - Ethan Perlstein (Ep. 11) 38:32

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2d ago38:32

38:32

In this episode, I talk to Ethan Perlstein, a YC biotech founder who wants to make better drugs and financial incentives for curing rare diseases. We discuss the post-academic collapse in science careers, the financial abandonment of most rare diseases, and how crypto and AI could revolutionize drug development.…

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#275 - Nick Bryant: Jeffrey Epstein’s Blackmail Empire | BIGGER Than You Were Told (Replay) 1:10:57

11d ago1:10:57

1:10:57

As the DOJ now claims no Epstein client list exists and Epstein-related files remain sealed, we’re re-releasing one of the most explosive interviews we’ve ever done. This is Part 2 of our deep dive with investigative journalist Nick Bryant, originally recorded in October 2024. Nick connects Epstein’s rise, from college dropout to Mossad-linked blac…

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Adam Becker on More Everything Forever and Big Tech’s Future Myths 2:09:27

20d ago2:09:27

2:09:27

Adam Becker is a science journalist with a PhD in astrophysics and the author of the provocative new book More Everything Forever: AI Overlords, Space Empires, and Silicon Valley’s Crusade to Control the Fate of Humanity. I reached out to Adam because I found his book sharp, timely, and necessary — a long-overdue reality check […]…

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Adam Becker on More Everything Forever and Big Tech’s Future Myths 2:09:27

20d ago2:09:27

2:09:27

Adam Becker is a science journalist with a PhD in astrophysics and the author of the provocative new book More Everything Forever: AI Overlords, Space Empires, and Silicon Valley’s Crusade to Control the Fate of Humanity. I reached out to Adam because I found his book sharp, timely, and necessary — a long-overdue reality check […]…

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#274 - Dr. Sander van der Linden: Is MISINFORMATION The Next Biological Weapon? 1:04:01

20d ago1:04:01

1:04:01

Professor Sander van der Linden’s fascination with misinformation traces back to his own family’s scars under Nazism, a regime that perfected propaganda so insidious it seeped invisibly into everyday life. In his award-winning book Foolproof, van der Linden argues that misinformation is a psychological virus, spreading through minds the way a biolo…

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The Ethics of Human Germline Editing with Francoise Baylis 44:26

1M ago44:26

44:26

In this episode, I speak with Professor Francoise Baylis, a renowned Canadian bioethicist whose work lies at the intersection of applied ethics, health policy, and practice. We talk about the ethics of research on human embryos -- at what date the line should be drawn -- and whether it practically and morally makes sense to allow for human germline…

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#273 - Otis Brown III: Do Music Schools Really BREAK You Like in Whiplash? 1:50:50

1M ago1:50:50

1:50:50

Otis Brown III didn’t just grow up around music, he was shaped by it. With a father who drummed for legends like James Brown and Al Green, and a mother who was a classically trained pianist and choir director, Otis was raised in a home where rhythm and soul were a way of life. In this episode, we trace Otis’s journey from early church gigs to Donal…

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The Future of Defense Innovation - Dave Brewer @ InnoTECH 47:04

2M ago47:04

47:04

In this conversation, we explore the intersection of military experience, technology, and leadership through the lens of Dave Brewer, a retired Air Force officer. He shares insights on burnout, the importance of enjoyment in work, and the evolving landscape of defense innovation, particularly in space strategy. The discussion delves into misunderst…

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#272 - Agent Steve Murphy: 400 Kilos, CIA Lies, and a $300K Hit | The Real DEA Story Of HUNTING Escobar 2:45:50

2M ago2:45:50

2:45:50

What does it take to bring down the most powerful drug lord in modern history? In this gripping episode, DEA Special Agent Steve Murphy, one of the agents who helped take down Pablo Escobar, joins me to unpack the truth behind the manhunt that inspired Netflix’s Narcos. From gunfights in Miami and undercover stings gone sideways, to the 18-month ch…

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Is Cryonics a Pseudoscience? - Ariel Zeleznikow-Johnston 1:34:00

2M ago1:34:00

1:34:00

In this episode we talked to Ariel Zeleznikow-Johnston, a research fellow at Monash University and author of The Future Loves You. This episode includes considerable debate between the hosts and the guest, as well as participation from a live audience at the Biostasis week at Vitalist Bay.Topics Discussed & Debated: * Why Ariel has used terms like …

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Angus Fletcher: Why AI Will Never Replace Human Storythinking or Primal Intelligence 1:56:23

2M ago1:56:23

1:56:23

In his second appearance on Singularity.FM, Professor Angus Fletcher returns to dive even deeper into the story of human intelligence. [See the first interview here.] Fletcher is no ordinary guest. A rare hybrid of neuroscientist and Shakespearean scholar, he has advised DARPA, Hollywood, and the U.S. Army, where his narrative-based research earned…

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Angus Fletcher: Why AI Will Never Replace Human Storythinking or Primal Intelligence 1:56:23

2M ago1:56:23

1:56:23

In his second appearance on Singularity.FM, Professor Angus Fletcher returns to dive even deeper into the story of human intelligence. [See the first interview here.] Fletcher is no ordinary guest. A rare hybrid of neuroscientist and Shakespearean scholar, he has advised DARPA, Hollywood, and the U.S. Army, where his narrative-based research earned…

1
Angus Fletcher on Storythinking and Primal Intelligence 1:56:23

2M ago1:56:23

1:56:23

In his second appearance on Singularity.FM, Professor Angus Fletcher returns to dive even deeper into the story of human intelligence. [See the first interview here.]Fletcher is no ordinary guest. A rare hybrid of neuroscientist and Shakespearean scholar, he has advised DARPA, Hollywood, and the U.S. Army, where his narrative-based research earned …

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#271 - Sgt. John Mattingly: Breonna Taylor, The RAID, & The Aftermath 1:59:42

2M ago1:59:42

1:59:42

What really happened the night of the Breonna Taylor raid? In this episode, retired Louisville Sergeant John Mattingly shares his firsthand experience from the 2020 police operation that became a national flashpoint. Shot in the leg during the raid that left Breonna Taylor dead, Mattingly takes us beyond the headlines and social media narratives. F…

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George Church -- The Godfather of Synthetic Biology, CRISPR, and De-Extinction (Ep. 10) 40:06

2M ago40:06

40:06

In this episode, I speak with George Church—pioneer of human genome sequencing, co-inventor of CRISPR, and founder of over 50 biotech startups—on the future of synthetic biology: virus-proof cells, multiplex gene editing, and what it takes to reverse aging. We talk Ginkgo’s trajectory, 23andMe’s missed opportunity, and why the next bio revolution w…

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The Mind-Bending Science of Staying Alive -- Carl Zimmer on Aging, AGI, and Brain Organoids (Ep. 9) 30:39

2M ago30:39

30:39

In this episode, I speak with award-winning NYT science writer Carl Zimmer (“Life’s Edge”, “She Has Her Mother’s Laugh”) on the verbs of biology—homeostasis, life being organized rebellion against entropy, and whether brain organoids might wake up while we’re not looking.

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#270 - Adam Butler: Conversations with GOD, Angels, & Aliens | Exploring DMT 2:34:24

3M ago2:34:24

2:34:24

On this episode of The Zach Show, Adam Butler and Zach discuss DMT, the psychedelic molecule that Adam claims saved his life. From suicidal despair in the desert to conversations with God, demons, and dimensional beings, Adam recounts his transformation through DMT with brutal honesty and poetic grit. We unpack the “Miracle Molecule” from every ang…

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Inside Lean Startup: What Actually Works in Big Companies - Ben Hefele @Lean Startup Co. 44:23

3M ago44:23

44:23

In this conversation, Ben Haefle, CEO of Lean Startup Co., discusses the realities of corporate innovation, emphasizing the importance of core innovation over disruptive innovation. He explains the Lean Startup methodology, focusing on strategic alignment, milestones, team roles, governance, and culture. The discussion also touches on the concept o…

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Jamie Metzl - Will Humanity Survive Gene Editing and AI? (Ep. 8) 44:22

3M ago44:22

44:22

In this episode, I talk with Jamie Metzl — geopolitical futurist, former WHO advisor, and author of Superconvergence — about the future of gene editing, AGI, and the existential risks no one is talking about. We cover CRISPR will rewrite evolution and society, and why AGI is a myth (and what we're really building).…

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#269 - Dr. José Loiaza & Dr. Julie Labau: The REAL Story Behind Mosquito-Borne Disease | From The Jungle To The Lab 1:57:47

3M ago1:57:47

1:57:47

On this episode of The Zach Show, Zach sits down with Dr. Jose Loiaza and Dr. Julie Labau to discuss mosquito-borne disease, the biggest myths about mosquitoes, whether we're on the brink of a supervirus pandemic, a recent research expedition to the Darien Gap, climate change, the origin of the coronavirus, Trump's threats to take over the Panama c…

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How GRAMMY Winners Are Really Chosen - Panos A. Panay @The Recording Academy 41:01

4M ago41:01

41:01

The truth behind the Grammy Awards 🏆 What does it really take to win? How are nominees selected, and what role does AI play in music today? Panos A. Panay, President of the Recording Academy, reveals everything - from the intense behind-the-scenes orchestration of music’s biggest night to how technology and creativity intersect. Get insider access …

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Mark Woodward - A Revolution in Cryoprotectants 1:01:11

4M ago1:01:11

1:01:11

In this episode of The Cryosphere Podcast, hosts Max Marty and Rebecca Ziegler sit down with Mark Woodward, founder of Wake Bio, who's applying cutting-edge AI techniques to solve one of cryonics' most fundamental challenges: developing superior cryoprotectants. With a background in AI/ML at Google Brain and Stanford, Mark explains how he's now usi…

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Aubrey de Grey on Immortality, Longevity Research, and How to Live for 200 Years (Ep. 7) 51:35

4M ago51:35

51:35

In this episode, I talk with Dr. Aubrey de Grey, a leading researcher in the longevity space and co-founder of the SENS Research Foundation, known for his groundbreaking work in developing therapies that reverse DNA damage at the cellular level. We talk about the latest breakthroughs in aging science, what aging research looks like in a post-AGI wo…

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#268 - James Mahaffey: The TERRIFYING History Of Atomic Accidents, The Manhattan Project, Chernobyl, Roswell, & The UFO Connection 2:06:36

4M ago2:06:36

2:06:36

On this episode of The Zach Show, Jim Mahaffey and Zach discuss how Jim became fascinated with nuclear history, the most infamous atomic weapons smuggler of all time, the high-risk environment of The Manhattan Project, what really went wrong at Chornobyl, a perfect explanation of what happened at Roswell, Cold Fusion, whether a nuclear powered Iron…

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Robert Langer: Founding Moderna and Publishing Over 1500 Research Papers (Ep. 6) 34:17

5M ago34:17

34:17

In this episode, I talk with Dr. Robert Langer, co-founder of Moderna and PI of the world’s largest biomedical engineering lab at MIT. We talk about his background, how to raise money for biotech ventures, and whether innovation can be born from the lab.

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The Man Who Used Gene Editing On Babies - He Jiankui (Ep. 5) 30:17

5M ago30:17

30:17

In this episode, I talk with Dr. He Jiankui, a gene editing pioneer who used CRISPR/Cas technology to edit the infamous twin babies Lulu and Nana. We talk about his goals, ethics behind the technology, and the potential for a utopian and dystopian future.

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#267 - The Rendlesham Forest UFO Encounter: NUCLEAR Weapons, Laser Beams, Glowing Crafts, & UAP Coverup 1:29:23

5M ago1:29:23

1:29:23

On this solo episode of The Zach Show, Zach discusses the infamous Rendlesham Forest UFO Encounter, the much less discussed first-hand witness accounts of the UFO visiting the nuclear storage facility with live tactical nukes, the radar readings of the crafts from the encounter, the case for UAP transparency, the future of humanity as a species not…

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#266 - BLACK SWAN Breakdown: Nina's Descent Into MADNESS, Lily Vs. Nina Rivalry, Fan Theories, & The Price Of Perfection | Dr. Julie Labau 1:38:40

5M ago1:38:40

1:38:40

On this episode of The Zach Show, Julie and Zach discuss Black Swan, more specifically the twisted journey of Nina's descent into madness, the erotic rivalry that unfolded between Lily and Nina, fan theories on the film, the price of perfection, and more. Guest bio: Dr. Julie Labau is a research scientist for the Smithsonian Tropical Research Insti…

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Immune-Based Therapies with Dr. Victor Nizet (Ep. 4) 47:50

5M ago47:50

47:50

Dr. Victor Nizet, Professor of Pediatrics and Vice Chair for Basic Research at UC San Diego details some of the innovative approaches being used in his lab to fight infectious disease, namely, host-targeted immune based therapies. We discuss many of the major problems in infectious disease, including antibiotic resistance, novel drug mechanisms, an…

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Antimicrobial Resistance with Dr. Carl Nathan (Ep. 3) 38:18

5M ago38:18

38:18

Dr. Nathan, a leading expert in microbiology and immunology, summarizes one of the most pressing problems in medicine: antimicrobial resistance. We discuss the evolution of drug resistance pathogens as well as the scientific, public health, and business frameworks that govern this problem. We finally discuss how the UN can come together to build et…

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Vaccines with Dr. Stanley Plotkin, "Godfather of Vaccines" (Ep. 2) 31:06

6M ago31:06

31:06

Dr. Stanley Plotkin is often hailed as the ‘Godfather of Vaccines.’ His pioneering work has not only led to the development of the rubella vaccine—critical in eradicating rubella across the Americas—but also propelled breakthroughs in vaccines for rabies, polio, and anthrax. We discuss breakthroughs in vaccine development, reducing public skepticis…

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Antimicrobial Stewardship with Dr. Alberto Giubilini (Ep. 1) 22:39

6M ago22:39

22:39

Dr. Alberto Giubilini, a philosopher and leading expert in bioethics, introduces one of the most pressing issues in public health: antibiotic overuse. We discuss how unchecked consumption of these life-saving drugs can lead to a “tragedy of the commons,” why some experts are calling for an antibiotic tax, and the broader ethica…

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#265 - Chris Cooper: Crazy By CONSCIOUS, Saving A Brother, New Jersey Drones, & Jiddu Krishnamurti 2:23:47

6M ago2:23:47

2:23:47

On this episode of The Zach Show, Chris Cooper and Zach discuss Chris' debut fiction novel 'Crazy By Conscious,' how Chris saved his brother's life in the hospital, the philosophy of Jiddu Krishnamurti, the collapse of Bed Bath & Beyond, Chris' firsthand New Jersey drone/UAP experience, and more. Guest bio: Chris Cooper is an award-winning writer, …

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#264 - Annette Nenner & Christian Hardinghaus: Still LOST In Panama | The Disappearance Of Kris Kremers & Lisanne Froon 2:38:50

6M ago2:38:50

2:38:50

On this episode of The Zach Show, Annette Nenner and Christian Hardinghaus discuss the disappearance of Kris Kremers and Lisanne Froon on the infamous Pianista Trail in Panama, the case analysis and elements of the disappearance that don't match up, the photos recovered from the SD card, accident versus crime theories, whether this case was covered…

Aubrey De Grey Podcasts