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Welcome to Basics to Brilliance, the Haematology podcast created to supplement & bolster your knowledge for the FRCPath Part 1. Featuring a two way, non-didactic conversational-style Q&A between the SpR and SHO, this podcast will be your pocket companion no matter where you are. We aim to cover: - Malignant and non-malignant topics - The whole syllabus for FRCPath part 1 - Review UK guidelines - Go into science/lab detail - Discuss how guidelines often translate into practice - Review and ap ...
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Feedback 0:52 Intro and table of contents 2:36 CASE 1- Infection, due surgery and a prolonged APTT ft. a refresher on APTT prolongation 08:00 Mixing studies- definition and uses ft. Hari’s exam nugget 17:00 Factor assays (1 stage, 2 stage and chromogenic assays) ft. David’s humorous humility 43:30 David applies his new-found knowledge to our first …
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Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrillia…
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1
Practical Haemostasis of the Clotting Screen
34:27
34:27
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Feedback 00:00 Intro 04:25 Automated Methods of Measuring a Clot 05:50 Scenario 1 & Pre-Analytical Variables 11:50 HIL Index & Patient Factors 15:55 Blood Tube Basics 21:10 Nitty Gritties- What Happens When We Send a PT? 23:20 PT vs INR for Warfarin- Going Down The Rabbit Hole... 26:35 Heparin Neutralising Buffer 29:00 APTT 33:05 Summary (& an hono…
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Feedback 0:00 Intro 2:45 What is Haemostasis? 3:55 Stages of Haemostasis (summary) 4:45 Primary Haemostasis 8:35 Secondary Haemostasis 11:10 The Clotting Cascade 12:20 Common + Extrinsic Pathway 13:50 Intrinsic Pathway (TwelvEleveNinEight) 14:25 Clotting Tests 16:30 Hari Pops The Bubble 18:05 In-Vivo vs. In-Vitro 22:20 Isolated PT Prolongation- cau…
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Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrillia…
…
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Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrillia…
…
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1
Heparin Induced Thrombocytopenia (HIT)
1:00:26
1:00:26
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Feedback 'Basics to Brilliance: Haematology Podcast' has been accredited for CPD credit by the Royal College of Pathologists UK. Medical professionals and clinical scientists holding career-grade positions, who are registered with any of the Royal Colleges for CPD, will be eligible to earn 1 credit for every hour of learning. Email: basicstobrillia…
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Feedback Polycythaemia- red cell # Erythrocytosis – in red cell mass Absolute Erythrocytosis - M: Hct >0.60 or >0.52 + RCM >25% of mean - F: Hct >0.56 or >0.48 + RCM >25% of mean Apparent Erythrocytosis - Men: Hct >0.52 + normal RCM - Women: Hct >0.48 + normal RCM Relative erythrocytosis -Normal RCM + Reduced plasma volume (pathological dehydration…
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Feedback - Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL) - CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-SCNSL) - Relapsed concomitant systemic and CNS disease following treatment for systemic lymphoma (RC-SCNSL) Generally hybrid disease Investigations - MRI Head w ga…
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Feedback CNS Lymphomas 1% of all NHL 3% of all Brain tumours Most common subtype (90%) is DLBCL Clinical division: 1. 1* CNS lymphoma, 2. 2* CNS lymphoma - TN-SCNSL - RI-SCNSL - RC-SCNSL 3. Immune deficiency assoc- HIV; better prog. Presentation: - SOL Sx - Raised ICP: morning headaches w N+V - Neuropsych, Behavioural, Memory, Language - Focal moto…
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Feedback Chronic MyeloMonocytic Leukemia (not CML) Persistently high monocyte count- 3 months Most frequent MDS/Myeloproliferative neoplasms – a cross between the two Median age 72 Median survival 20-40 months Transformation to AML (15-30%) WHO definition of CMML: 1. Excess monocytes- persistent over 3 months, ≥ 1 - Monocytes 10% of total WC count …
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Feedback Chronic Lymphocytic Leukemia (CLL)- Chronic Relapsing Remitting Most common leukemia in adults Incurable but treatable *Remember Supportive Care* Median age of 72 M > F 80% incidental SLL: lymphocytes in lymph nodes and spleen instead of blood Presentation: 1) Fatigue 2) B symptoms 3) High WC 4) Cytopenias (Marrow infiltrate, AIHA, ITP, Hy…
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