Andreessen Horowitz ("a16z") co-founders Marc Andreessen and Ben Horowitz explore everything from science to business to culture, all through the lens of technology.
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Marc Andreessen Podcasts
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Learn from history's greatest entrepreneurs. Every week I read a biography of an entrepreneur and find ideas you can use in your work. This quote explains why: "There are thousands of years of history in which lots and lots of very smart people worked very hard and ran all types of experiments on how to create new businesses, invent new technology, new ways to manage etc. They ran these experiments throughout their entire lives. At some point, somebody put these lessons down in a book. For v ...
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Conversations about science, technology, history, philosophy and the nature of intelligence, consciousness, love, and power. Lex is an AI researcher at MIT and beyond.
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Host Mike Maples Jr. from venture capital firm Floodgate offers lessons from the rare startup super performers — BEFORE they were successful. Pattern Breakers features interviews with some of Silicon Valley’s most legendary entrepreneurs and thought leaders, including Netscape co-founder Marc Andreessen, LinkedIn founder Reid Hoffman, Instagram founders Kevin Systrom and Mike Kreiger, business maverick Mark Cuban, and Shopify co-founder Tobi Lütke.
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Stripe cofounder John Collison interviews founders, builders, and leaders over a pint.
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A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vineeta Agarwala, Julie Yoo, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg Verdine, Fei-Fei Li, and Suchi Saria, as they explore the i ...
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How do you grow like a VC-backed SAAS company without taking on investors? What are the secrets that SAAS CEOs have that the rest of us don't? Do you want to create a lifestyle business, a performance business, or an empire? How do you scale to an exit without losing your freedom? Join the host Ryan Staley every Monday and Wednesday for conversations with the brightest and best SAAS Founders, CEOs, and Entrepreneurs to crack the code on repeatable revenue growth, leadership, lifestyle freedo ...
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Interviews with the top Investors, CEOs, & Founders
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Most business podcasts follow a similar format: find a successful CEO and have them tell their story. This is not that show. Zero to IPO tackles real world problems with real world experience, featuring actionable advice and anecdotes from some of the world's most innovative founders. In season one, we broke down each stage of a company's growth cycle on a granular level with everyone from Parker Harris of Salesforce.com, to Julia Hartz of Eventbrite and Marc Andreessen of Andreessen Horowit ...
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You’ll hear consequential ideas here first, and in the mainstream months later. Upstream is a curated nexus feed from the Turpentine podcast network, bringing you expert-level conversations hosted by some of the most compelling thinkers in the world including Noah Smith, Samo Burja, Byrne Hobart, Erik Torenberg, and Nathan Labenz. Guests include Marc Andreessen, Balaji Srinivasan, Dario Amodei, Brian Armstrong, David Sacks, Sam Harris, Katherine Boyle, Curtis Yarvin, and many more unmissable ...
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Your shortcut to startup wisdom. Each week, The Seminal Startup brings to life the most important, iconic, and game-changing articles ever written about building and scaling startups. Whether it's Paul Graham, Marc Andreessen, Elad Gil, or other legends of the ecosystem, we just read their words. We don't editorialize or talk about the content. This is just a startup to help you read these articles too. Perfect for founders, operators, investors, and anyone obsessed with the art of entrepren ...
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Chats between Duncan Anderson and James Peck on anything we find interesting... hopefully you find it interesting as well :) Please note all statements are the individuals own and do not represent the organisations they work for.
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Tech Talks
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Listen to your long form article at your leisure
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What if we all stopped to think a little harder? To have conversations with each other? What might the world look like? I’m Kinsey Grant and together, we’re gonna find out.
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Bill Bennett discusses the news of the day and why it matter. Clear and candid conversations with special guests who are "in the know".
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w/ Jennifer Sutto & Michael Keen: NFTs are going mainstream. Jennifer & Michael keep their audience informed about all relevant projects as the industry continues to expand. With a focus on market dynamics and turning a profit, this podcast is perfect for the seasoned NFT trader or someone that is just looking to learn what the heck is going on with these JPEGS!
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We’re witnessing a revolution in retail investing, and personal finance is more culturally relevant than ever before. Now, new questions are emerging about how our financial system works—and how it needs to change to better serve everyday people. In this podcast, we’re lifting the hood on the world of investing and exploring what it really means to democratize finance for all. Join Robinhood CEO and Co-Founder Vlad Tenev as he interviews the most interesting minds in money today—from YouTube ...
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We launched Navigating Our World in 2008 to mark our 10th anniversary as an independent firm. Each NOW conference—this year would have marked our seventh—is meant to embody our commitment to seeking out fresh and diverse views, learning from experts across disciplines, and challenging conventional assumptions. While we have shifted our conference format to a podcast series due to the pandemic, we remain steadfast in our belief that thoughtful inquiry, encompassing varied perspectives, helps ...
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Half a billion people can access the world’s best AI on their phone. So why are most using it to write emails while only some are using it to build empires? In this conversation with Mark Halperin from Next Up, Marc Andreessen reveals why small bakeries are beating Fortune 500 companies at AI adoption, how to turn ChatGPT into your personal board o…
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Why Marc Andreessen, Ben Horowitz, & David Ulevitch Launched American Dynamism
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28:06David Ulevitch, General Partner at Andreessen Horowitz (a16z), who co-leads the firm’s American Dynamism practice with Katherine Boyle joins Sourcery to break down America’s comeback. With the encouragement of Marc Andreessen and Ben Horowitz, the $600M fund was founded around 2020 to invest in companies that support the national interest: aerospac…
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The $700 Billion AI Productivity Problem No One's Talking About
58:17
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58:17Russ Fradin sold his first company for $300M. He’s back in the arena with Larridin, helping companies measure just how successful their AI actually is. In this episode, Russ sits down with a16z General Partner Alex Rampell to reveal why the measurement infrastructure that unlocked internet advertising's trillion-dollar boom is exactly what's missin…
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Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep486-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcript: https…
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What Travis Kalanick Taught Bradley Tusk, & Why He Closed His VC Fund
1:12:18
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1:12:18Bradley Tusk joins Sourcery to discuss what he learned working closely with Travis Kalanick during Uber’s early regulatory battles, and how those experiences shaped his decision to shut down his venture fund and return to an equity-for-services model. Bradley explains why Travis was unusually fast, analytical, and willing to challenge institutions,…
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How OpenAI Builds for 800 Million Weekly Users: Model Specialization and Fine-Tuning
53:24
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53:24In this episode, a16z GP Martin Casado sits down with Sherwin Wu, Head of Engineering for the OpenAI Platform, to break down how OpenAI organizes its platform across models, pricing, and infrastructure, and how it is shifting from a single general-purpose model to a portfolio of specialized systems, custom fine-tuning options, and node-based agent …
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92. Is there an AI bubble? Thoughts On What Markets Are Really Pricing In. Mentioning Warren Buffet, Paul Volcker, Larry Page & More
1:05:35
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1:05:35This blog is the best explanation of AI intelligence increase I've seen: https://metr.org/blog/2025-03-19-measuring-ai-ability-to-complete-long-tasks/### Defining Market Bubbles- Traditional definition: 20%+ share price decline with economic slowdown/recession- Alternative perspective: hype/story not matching reality over time (dot-com example)- Du…
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Ben Horowitz: Why Open Source AI Will Determine America's Future
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46:50Ben Horowitz reveals why the US already lost the AI culture war to China—and it wasn't the technology that failed. While Biden's team played Manhattan Project with closed models, Chinese developers quietly captured the open-source heartbeat of global AI through DeepSeek, now running inside every major US company and university lab. The kicker: Goog…
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The Secret Marketing Strategy That Built a16z: From Zero to Legendary VC Firm
58:30
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58:30Marc Andreessen and Ben Horowitz sit down with Margit Wennmachers—the woman who turned two unknown entrepreneurs with $300 million and zero investing track record into the most talked-about firm in venture capital. She unpacks how they weaponized transparency in an industry built on secrecy, why Fortune's cover story triggered a cartel meltdown, an…
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The Secret Marketing Strategy That Built a16z: From Zero to Legendary VC Firm
59:55
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59:55Marc Andreessen and Ben Horowitz sit down with Margit Wennmachers—the woman who turned two unknown entrepreneurs with $300 million and zero investing track record into the most talked-about firm in venture capital. She unpacks how they weaponized transparency in an industry built on secrecy, why Fortune's cover story triggered a cartel meltdown, an…
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I'm reposting one of my favorite founder stories. If you listened to this first time I recommend listening again. If you missed this before, you're about to hear one of the wildest founder stories of all time. A few surprising things I learned from reading about Dietrich Mateschitz, founder of Red Bull: 1. He started the company when he was 41 year…
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Julia DeWahl of Antares on building nuclear reactors for the US military
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45:17Julia DeWahl is the cofounder of Antares, a company developing nuclear micro-reactors for the US military and critical infrastructure. She sits down with John to discuss the vision for the "Starlink of electricity", and why AI hyperscalers are driving a nuclear renaissance. They cover the bipartisan shift in nuclear regulation (and why the NRC’s ol…
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Inside Thrive Capital: Investing in OpenAI, Wiz, Cursor, Nudge, Physical Intelligence
57:43
57:43
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57:43Thrive Capital Partner Philip Clark joins Sourcery to break down how one of the most concentrated and influential firms in tech evaluates founders, builds conviction, and partners with companies that reshape the world. “Josh always had a line to me when I joined Thrive, which is that the people who win deals are the ones who want to win them most.”…
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The Future of Healthcare Payments: CMS Chief of Staff Stephanie Carlton
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26:53A labor and delivery nurse who ran Senate healthcare policy now manages $1.7 trillion in federal health spending—and she runs her team like a startup. Steph Carlton, Chief of Staff and Deputy Administrator at CMS, reveals the OKRs driving Medicare and Medicaid, why they're killing social determinants funding while building consumer health apps at s…
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The 2045 Superintelligence Timeline: Epoch AI’s Data-Driven Forecast
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1:00:10Epoch AI researchers reveal why Anthropic might beat everyone to the first gigawatt datacenter, why AI could solve the Riemann hypothesis in 5 years, and what 30% GDP growth actually looks like. They explain why "energy bottlenecks" are just companies complaining about paying 2x for power instead of getting it cheap, why 10% of current jobs will va…
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$635M Exit → $600M Fund: David Ulevitch on Building a16z’s Hottest New Fund
27:57
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27:57a16z General Partner David Ulevitch joins Sourcery to break down the real state of American Dynamism, their $600M fund, across defense, energy, mining, robotics, manufacturing, public safety, and national security. We discuss America’s supply-chain exposure to China, why deterrence—not parity—defines the future of U.S. defense, and how new companie…
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Google's Gemini 3 Just Prepped My $200K Sales Call in 15 Minutes
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13:40Google just released Gemini 3, and I tested it with 3 real business use cases: prepping for a $200K sales call, building an interactive sales dashboard, and creating a complete website from scratch—all in minutes.In this video, I show you LIVE examples of:✅ Gemini Agent prepping an entire sales call (research, pitch angles, objection handling, foll…
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Robinhood CEO: Making Everyone An Owner
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1:05:02Vlad Tenev built Robinhood by breaking every rule Wall Street wrote: zero commissions when competitors charged $10, mobile-first when "serious" investors demanded desktop, a brand that made finance feel like rebellion instead of a club you'd never join. By 2021 they'd forced every major brokerage to slash fees and attracted millions who'd never own…
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Can Community Banks Survive the Next SVB? | ModernFi CEO Paolo Bertolotti and Former Comptroller Gene Ludwig
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43:42The former bank regulator who invented deposit networks just revealed why SVB's collapse was inevitable—and why the solution that could have saved them is finally being rebuilt. Gene Ludwig ran the OCC during the Clinton administration, created a half-trillion-dollar market solving a problem his Aunt Betty faced riding buses between banks, then wat…
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Why Silicon Valley Turned Against Defense (And How We’re Fixing It)
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1:14:47Palmer Luckey got fired from Meta for backing the wrong candidate—now he's the hero saving American defense, and that shift tells you everything about how fast the ground moved beneath Silicon Valley's feet. For decades, tech and defense were allies, then came 15 years of hostility so visceral that Google employees revolted over a Pentagon AI contr…
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Ben Horowitz & Marc Andreessen: Why Silicon Valley Turned Against Defense (And How We’re Fixing It)
1:16:13
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1:16:13Palmer Luckey got fired from Meta for backing the wrong candidate—now he's the hero saving American defense, and that shift tells you everything about how fast the ground moved beneath Silicon Valley's feet. For decades, tech and defense were allies, then came 15 years of hostility so visceral that Google employees revolted over a Pentagon AI contr…
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Wade Foster: Why Zapier is Built for the AI Revolution
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42:16When Wade Foster was a kid growing up in Jefferson City, Missouri, there weren’t many models for how to carve out a career in entrepreneurship. But when he and his friend Bryan Helmig developed an easier way to help users connect web-based applications, they ushered in what would eventually become Zapier, a remote automation giant that’s now worth …
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Satya Nadella describes how lessons from Microsoft’s history apply to today’s boom
1:18:51
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1:18:51Satya Nadella, CEO of Microsoft, sits down with John to discuss the diffusion of AI inside the enterprise. He explains why “all your data at your fingertips” is the evergreen pitch, why this AI CapEx cycle is different from the .com bubble, and his vision for "agentic commerce". They also cover Microsoft's product bundling strategy and how he "wand…
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#485 – David Kirtley: Nuclear Fusion, Plasma Physics, and the Future of Energy
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2:45:22David Kirtley is a nuclear fusion engineer and CEO of Helion Energy, a company working on building the world’s first commercial fusion power plant by 2028. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep485-sc See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. Transcr…
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This episode covers the insanely valuable company-building principles of John D. Rockefeller—and nothing else. I spent over 40 hours reading (and rereading) this obscure biography of Rockefeller that costs $1,000 I then spent several days editing down 25 pages of notes from the book. I deleted everything that was not How Rockefeller Works Episode s…
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Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering
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1:10:36Emmett Shear, founder of Twitch and former OpenAI interim CEO, challenges the fundamental assumptions driving AGI development. In this conversation with Erik Torenberg and Séb Krier, Shear argues that the entire "control and steering" paradigm for AI alignment is fatally flawed. Instead, he proposes "organic alignment" - teaching AI systems to genu…
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How to Build This Generation's Big Pharma Company
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41:04Drug discovery has doubled the flow of candidates, but approvals remain roughly flat. The constraint is development, not discovery. In this episode, a16z General Partner, Jorge Conde talks with Formation Bio cofounder and CEO Ben Liu about building a modern pharma company around clinical execution. They discuss Formation Bio’s hub-and-spoke model f…
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GPT-5.1's 3 Superpowers that No One Is Talking About
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17:21**GPT-5.1 just changed the AI game with 3 superpowers most people are completely missing.** In this complete guide, I break down exactly how to use Speed + Warmth, Adaptive Reasoning, and Instruction-Following Precision to 10x your productivity in sales, marketing, and strategy.**What You'll Learn:**✅ How to choose between GPT-5.1 Instant and Think…
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Can America Win The AI Biotech Race Against China? | Lada Nuzhna & Elliot Hershberg
1:02:23
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1:02:23Two venture capitalists dissect why biotech burns billions while China runs trials in weeks—and why the next Genentech won't look anything like the last one. Elliot Hershberg reveals the "three horsemen" strangling drug development as costs explode to $2.5 billion per approval, while Lada Nuzhna exposes how investigator-initiated trials in Shanghai…
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The Frontier of Spatial Intelligence with Fei-Fei Li
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44:11Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, they have long been laying the groundwork for the innovations transforming industries today. With the recent launch of Marble, the first product from their company World Labs, we are revisiting this conversation to explore the ideas…
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Rocket Companies CEO: Here’s How to Fix the Housing Crisis
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55:55The Empire State Building took 110 days to build—today, changing a window would take two years. Alex Rampell (a16z) and Varun Krishna (Rocket CEO) expose how asset inflation turned housing from the American Dream into a wealth transfer machine where the median homebuyer age jumped from 30 to 38 in just fourteen years. While Silicon Valley burns bil…
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Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users
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53:17Grant Lee was told Gamma was "the worst idea ever heard" by an investor who hung up mid-Zoom—yet he built it to 100 million users and $100M ARR without spending a dollar on advertising. While competitors hired aggressively, Grant's team of seven refused to grow, dedicating 25% of their tiny team to design and personally onboarding every influencer …
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Alex Karp, CEO of Palantir: Exclusive Interview Inside PLTR Office
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40:57Alex Karp, CEO of Palantir, joins Molly O’Shea for a rare look inside Palantir (physically, inside their office). We go deep into their values, vision, and the moral foundation of technology in the AI era. Fresh off Palantir’s record-breaking earnings, nearly hitting a $500 billion market-cap milestone, and the release of a new biography The Philos…
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Dave Ricks, CEO of Eli Lilly, on GLP-1s and the business of pharma
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2:05:15Dave Ricks, the CEO of Eli Lilly, the world's most valuable pharmaceutical company, sits down with John and Patrick to discuss the complex business of drug development. Dave explains the true origin story of GLP-1s (from Gila monster saliva), why their potential goes far beyond weight loss to addiction and inflammation, and how "self-pay" has becom…
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Michael Truell: How Cursor Builds at the Speed of AI
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27:30When four MIT grads decided to build a code editor while everyone else was building AI agents, they created the fastest-growing developer tool ever built. Cursor CEO Michael Truell joins a16z’s Martin Casado to discuss the deliberate constraints that led to breakthroughs: why they rejected the "democratization" narrative to focus on power users, ho…
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CVS Health: Building Healthcare’s Consumer Platform
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27:53Josh Weiner left Meta to return to CVS Health with two painful realizations: consumers don't manage their health—they expect it, and the healthcare market fundamentally violates every principle of economics. In this conversation with a16z's Julie Yoo, the CVS Senior VP explains why 50% of Americans can't afford a healthcare emergency, how CVS is be…
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Todd Graves is one of my favorite living founders. He owns over 90% of Raising Canes — a business that is worth at least $20 billion. Todd's maxim is "Do one thing and do it better than anyone else." It is impossible not to be inspired by his terminator levels of determination. I hope you enjoy our conversation as much as I did. Episode show notes:…
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a16z's State of Crypto: The $4 Trillion Milestone and What's Next'
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1:38:31The regulatory environment has completely inverted. Stablecoins are now a top 20 holder of US treasuries. Every major bank wants in. In a16z Crypto's 2025 State of Crypto report, Daren Matsuoka (Head of Data) and Eddy Lazzarin (CTO) reveal how crypto hit $4 trillion market cap while fundamentally reshaping how institutions think about payments, wit…
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This CEO Built a Daily AI Agent That Searches the Web While He Sleeps
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40:15Summary In this conversation, Chris Savage discusses the evolving landscape of entertainment and the importance of trust in video content. He highlights the current phase of shock and awe in video production, driven by advancements in technology that blur the lines between reality and fiction. Savage emphasizes that as audiences become accustomed t…
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Dyno Therapeutics: Empowering Patients with Genetic Agency
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47:28For the first time in human history, we can diagnose thousands of genetic diseases—often for under $1,000—but we still can't treat most of them. The problem isn't understanding what's broken; it's delivering the fix to the right cells. Eric Kelsic, CEO of Dyno Therapeutics, joins a16z's Jorge Conde to explain how AI-designed protein shells are solv…
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Amjad Masad & Adam D’Angelo: How Far Are We From AGI?
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1:02:44Adam D’Angelo (Quora/Poe) thinks we're 5 years from automating remote work. Amjad Masad (Replit) thinks we're brute-forcing intelligence without understanding it. In this conversation, two technical founders who are building the AI future disagree on almost everything: whether LLMs are hitting limits, if we're anywhere close to AGI, and what happen…
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Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease
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45:21Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional…
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Seeing The Future from AI Companions to Personal Software
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50:20Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exposes why command-line AI interfaces are the new MS-DOS, explains how mini-apps will become as shareable as TikToks, and details her decade-long journey…
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ElevenLabs CEO: Why Voice is the Next AI Interface
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31:14ElevenLabs CEO and co‑founder Mati Staniszewski joins Jennifer Li to explain how the team ships research‑grade AI at lightning speed—from text‑to‑speech and fully licensed AI music to real‑time voice agents—and why voice is the next interface for human‑computer interaction. He shares the small, autonomous team model, global hiring approach, and how…
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Stablecoin special: Zach Abrams (Bridge) and Henri Stern (Privy)
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1:14:09Zach Abrams, the CEO and cofounder of Bridge, the leading stablecoin orchestration platform, and Henri Stern, CEO and cofounder of Privy, the leading crypto wallet infrastructure, sit down with John to discuss the future of stablecoins, issuing, and what it will take for crypto to become ubiquitous. Both companies recently joined Stripe, and are un…
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