“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”. Will Rogers We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from t ...
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Light as Medicine: How Natural Light Cycles Impact Health and Longevity
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33:59Send us a text The rhythms of nature have orchestrated human biology for millennia, but our modern lifestyle has disconnected us from these essential patterns. Dr. Mark Pettus takes us on a fascinating journey through the science of circadian rhythms, revealing how light serves as crucial information that synchronizes every cell in our bodies with …
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Beyond Ozempic: The Natural Pathways to Enhanced GLP-1 Production
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41:22Send us a text Curious about natural alternatives to expensive GLP-1 medications like Ozempic? Dr. Mark Pettus unveils powerful nutritional strategies to boost your body's own GLP-1 production for improved metabolic health and sustainable weight management. This eye-opening presentation dives into the fascinating relationship between your diet, gut…
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Playing with Fire: How Modern Lifestyle Fuels Inflammation
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39:01Send us a text Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as "the cause of everything" and introduces the concept of "inflammaging" – how chronic inflammation accelerate…
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Epigenetics: How well do you fit into your genes?
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37:48Send us a text Prepare to have your understanding of genetics completely transformed. The revolutionary science of epigenetics reveals that you're not simply a prisoner of your DNA – you're actively participating in how your genes express themselves through every choice you make. Dr. Mark Pettus takes us on a fascinating journey through this emergi…
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Creatine: The Underrated Powerhouse for Muscle and Brain Health
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31:45Send us a text Creatine might be the most underappreciated nutritional powerhouse in our health toolkit. While many associate it exclusively with weightlifters and athletes, the science reveals a molecule with profound benefits reaching far beyond the gym. Mark Pettus MD and John Bagnulo PhD,MPH dive into creatine's fundamental role in human physio…
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Unlocking the Power of Protein: Transform Your Health with Optimal Intake and Lean Body Mass Maintenance
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40:33Send us a text Unlock the secrets to a healthier, longer life by mastering the science behind protein intake. Discover the critical role of animal protein in maintaining lean body mass, boosting metabolic health, and combating age-related muscle loss. We challenge traditional views and outdated guidelines, bringing you insights from recent research…
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Does Eating More Eggs Reduce Alzheimer's Disease Risk?
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29:55Send us a text In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition. https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihub https://www.thehealthedgepodcast.comBy Mark Pettus MD and John Bagnulo PhD, MPH
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Insulin Resistance: The Primary Driver of Modern Disease
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53:09Send us a text In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of li…
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Statin Use, LDL Reduction and the Magnitude of Cardiovascular Benefit
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30:54Send us a text In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention. JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022. https://pubmed.ncbi.nlm.nih.gov/…
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Exploring the Health Benefits of Saturated Fats and Full-Fat Dairy
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41:46Send us a text Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadeca…
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Red Meat and Diabetes: More than Meets the Eye
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14:58Send us a text In a world where health advice is abundant, it can be challenging to sift through conflicting data and headlines. One such contentious issue is the connection between red meat and type 2 diabetes. On this episode of The Health Edge, we take a critical look at this connection and aim to provide a balanced perspective on this often pol…
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Body Mass Index (BMI): Is it time to abandon this surrogate marker of metabolic health and mortality risk?
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14:39Send us a text Ready to have your understanding of BMI flipped on its head? We're diving into an intriguing study that suggests a BMI lower than 25 might be linked with decreased mortality. That's right, what you've been told about the ideal BMI could be all wrong. We also tackle the waist to hip ratio, showing you how to measure it and why it migh…
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Understanding the Complex World of Proteins, Essential Amino Acids, and the Role of IGF-1 in Brain Health
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43:53Send us a text Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference int…
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Powerful Lifestyle Medicine Interventions
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1:07:26Send us a text In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downlo…
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Send us a text In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigen…
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Send us a text In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk. Papers referenced: https://www.nature.com/articles/s4159... https://bmjopen.bmj.com/content/6/6/e... https://www.ncbi.nlm.nih.…
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Does excessive sodium restriction lead to insulin resistance?
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35:30Send us a text In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall …
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Sodium Restriction in Hypertension: Is too low dangerous?
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53:51Send us a text This is a replay of a prior podcast examining the relationship between sodium and hypertension. A growing body of research suggests there is a point below which e.g. 3,000 mg/day where risk is increased. This recording is a prelude to our upcoming podcast on sodium restriction and insulin resistance.…
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Erythritol and Cardiovascular Risk: Is there a real concern here?
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25:22Send us a text In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective. https://www.nature.com/articles/s41591-023-02223-9 Another recent review of risks and…
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Chronic Kidney Disease (CKD): An under recognized cardiovascular complication
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49:19Send us a text In this Health Edge recording Mark and John review recent data on the prevalence of CKD in the US. They review common drivers of CKD and offer many lifestyle medicine recommendations for prevention and management.By Mark Pettus MD and John Bagnulo PhD, MPH
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Time Under the Load:The critical relationship between muscle mass, cognition and all-cause mortality
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37:47Send us a text In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater ris…
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Alzheimer's and Mild Cognitive Impairment (MCI): Is this epidemic a one-way street?
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44:43Send us a text Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals…
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Send us a text Cardiovascular disease continues to be the #1 cause of mortality in the US and around the world. In this episode of The Health Edge, Mark and John review a paper that begins to address why it is that as we age, our risk for cardiovascular disease (CVD) and all other "age-related diseases" goes up dramatically. In this 2021 paper from…
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The Omega-6 to Omega-3 Fat Ratio as a Predictor of Health and Longevity
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44:49Send us a text In this recording of The Health Edge, Mark and John discuss the importance of dietary intake and sources of omega 6 and omega 3 fats. An abundance of epidemiological and clinical trials suggest high ratios of O-6/O-3 drive increased inflammation, oxidative stress and are associated with increased cardiovascular and all-cause mortalit…
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Saturated Fat Intake and Diabetes-Cardiovascular Risk
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38:22Send us a text In this episode of The Health Edge Mark and John review some recent studies that continue to challenge the long held belief that saturated fatty acid intake (SFAs) is directly linked to diabetes and cardiometabolic risk. https://www.thelancet.com/article/S0140-6736(17)32252-3/fulltext https://pubmed.ncbi.nlm.nih.gov/36056919/…
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An interview with Mark Campbell PhD on the relationship between time in Nature and Health
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49:31Send us a text In this recording of The Health Edge, Mark and John interview Mark Campbell PhD. We discuss the science linking time in Nature with global health outcomes. About Mark Campbell: Dr. Mark A. Campbell uses his background in wellness, sports medicine, exercise science, and performance psychology to impact change across all areas of life.…
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Send us a text In this latest Health Edge video John and Mark discuss their perspectives on protein intake. How much? Animal versus plant?By Mark Pettus MD and John Bagnulo PhD, MPH
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Cardiometabolic Health: Are you a member of this exclusive club?
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38:06Send us a text In this episode of The Health Edge Mark and John review a recent study published by the Journal of the American College of Cardiology, Trends and Disparities in Cardiometabolic Health Among U.S. Adults, 1999-2018. Mark and John reflect on how we got here and why this is so important to recognize and respond to. Lifestyle drivers and …
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Fructose, Uric acid and Cardiometabolic Risk
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39:26Send us a text Is it possible that consuming too much fruit could be detrimental to your health? Are all fruits the same? In this recording of The Health Edge Mark and John will explore the relationship between dietary fructose intake (from sugar and high fructose corn syrup and fruits), endogenous metabolic conversion of glucose to fructose (high …
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Do higher vitamin D levels slow biologic aging?
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33:11Send us a text In this episode of The Health Edge Mark and John review two papers that suggest higher levels of vitamin D via supplementation may slow our biologic clocks as measured by epigenetic methylation patterns. The implications are fascinating! YouTube link: https://youtu.be/O3UD62Pk9fE Papers reviewed: Vitamin D supplementation is associat…
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Can Healthy Lifestyle Reverse Biologic Age?
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40:47Send us a text In this episode of The Health Edge Mark and John review a recently published paper affirming proof of concept: healthy lifestyle may in fact reverse biologic aging or slow "biologic clocks" via epigenetic methylation patterns. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical tr…
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Science of Aging and Longevity Overview
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1:53:34Send us a text In this episode of The Health Edge, Mark shares a recording from January 21, 2022 reviewing the current science of aging and longevity. This was the first of a series of 6 webinars sponsored by OLLI Berkshires. https://berkshireolli.org/ScienceOfAgingWinter22 The pdf handout from this presentation can be downloaded at www.thehealthed…
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Send us a text In this episode of The Health Edge Mark and John review a paper demonstrating significant reductions in NAFLD with both 5:2 fasting mimicking or LCHF over just 12 weeks. Article can be found at: https://reader.elsevier.com/reader/sd/pii/S258955592100032X?token=5364332DCA18EABB9179131EF7F061F8AE705EE83CE947284A96CC9749AC9AF4E4C9FDA2D1…
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Chronology of Insulin Resistance, Obesity and Inflammation
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23:08Send us a text In this episode of The Health Edge mark and John review an important paper that suggests obesity to be more a consequence of higher insulin than a cause. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2749271By Mark
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Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality
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31:14Send us a text In this Health Edge podcast, John and Mark review a recent paper published in the New England Journal of Medicine that links higher intake of high-glycemic foods and beverages with higher all-cause mortality and cardiovascular disease. https://www.nejm.org/doi/full/10.1056/NEJMoa2007123…
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YOUR ROADMAP TO OPTIMAL HEALTH WITH Dr. Mark Pettus
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47:33Send us a text Drew Pearlman Interview: Dr. Mark Pettus is a triple-board certified Internist, Nephrologist, and Integrative Medicine physician practicing for over 25 years. He is also the author of two books, The Savvy Patient: The Ultimate Advocate for Quality Health Care and It’s All in Your Head: Change Your Mind, Change Your Health. He hosts T…
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Integrative Strategies to Support Mind and Mood Health
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1:28:26Send us a text This is a recently recorded presentation for the 2021 Physicians for Ancestral Health Symposium.By Mark
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Send us a text In this videocast of The Health Edge Mark and John review some research linking higher intake of microbiota associated carbs (MAC) with biome diversity and health outcomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143995/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896489/By Mark
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UVB Light: Why some xposure is so important for health
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35:50Send us a text In this Health Edge podcast, John and Mark review a paper that reviews the many effects of UVB light on the skin and systemic neuroendocrine and immune systems. They discuss the importance of photobiomodulation and the health implications. For mind, mood, pain, and inflammation, our sophisticated skin and retinal chromophores are qua…
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Ancestral Health: Was the advent of agriculture really a "catastrophe"?
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43:39Send us a text In this Health Edge recording Mark and John review a paper by Pulitzer Prize winning journalist Jared Diamond PhD. In this paper, Dr. Diamond suggested, "The adoption of agriculture, supposedly our most decisive step toward a better life, was in many ways a catastrophe from which we have never recovered."…
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Send us a text n this videocast, Mark and John review the stunningly low prevalence of metabolic health in US adults and offer some reflections on how best to improve this critical dimension of health and longevity.By Pettus and Bagnulo
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The Health Edge: Metabolic Health and Flexibility
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37:57Send us a text In this videocast, Mark and John review the stunningly low prevalence of metabolic health in US adults and offer some reflections on how best to improve this critical dimension of health and longevity.By Pettus and Bagnulo
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