The Scientist’s LabTalk is a special edition podcast series produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research.
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Synthetic Screens, Genes, and De Novo Proteins: Training AI Models with More Sequence Diversity to Improve Hits
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17:12Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dism…
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Synthetic Screens, Genes, and De Novo Proteins: Multiplexed Gene Fragments Drive De Novo Protein Design
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12:50Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dism…
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Synthetic Screens, Genes, and De Novo Proteins: Engineering Gene Regulation through Creative Experimental Design
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16:34Synthetic technologies allow scientists to venture into uncharted waters, asking unique research questions and finding previously unattainable solutions to some of life’s biggest mysteries. From gene editing to protein engineering, synthesized DNA libraries enable researchers to grasp once unreachable high-throughput screening applications and dism…
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Science Philosophy in a Flash: Demystifying Cell Culture Through Oxygen Analysis
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3:07With a track record of invention and translating technology into practical solutions, Walker Inman continues to drive innovation in the life sciences field. Inman is currently the cofounder and CEO of Lucid Scientific Inc., a company that develops cellular analysis tools. In this Science Philosophy in a Flash podcast episode brought to you by Lucid…
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Science Philosophy in a Flash: Curiosity and Compassion Fuel Rare Disease Research
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2:41Lauren Drouin is the director of analytical development and the Genomic Medicine Unit at Alexion AstraZeneca Rare Disease. As a dynamic scientist with unique expertise in current research and industry trends for gene therapies, Drouin is passionate about driving progress within the rare disease field and advancing products from preclinical developm…
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Hijacking Viruses: Optimizing Lentivirus-Based Cell Engineering
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14:01Researchers commonly employ lentiviruses to modify cells genetically. However, they must overcome several challenges when using these viruses in the laboratory or clinic. In this episode, Charlene Lancaster from The Scientist’s Creative Services Team spoke with Filippo Rossignoli, instructor in neurosurgery at the Center for Stem Cell and Translati…
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Molecular Diagnostics: An Eye Toward the Future - Real Time Diagnostics: Improving HPV Screening with PCR
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12:30Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts abo…
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Molecular Diagnostics: An Eye Toward the Future - Considerations for Oncology Biomarker Testing
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13:27Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts abo…
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Molecular Diagnostics: An Eye Toward the Future - Modernizing Molecular Diagnostics, from Assay Development to Routine Testing
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8:15Scientists commonly use qPCR applications in molecular diagnostics to detect pathogens, assess viral loads, or uncover mutations. While the qPCR assay itself may seem straightforward, other aspects such as data collection and security, and following regulatory guidelines, present challenges. In this episode, Gloria Lam, the associate director of qP…
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Molecular Diagnostics: An Eye Toward the Future - The Simple Solution of Saliva
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12:39Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers a…
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Building Bridges for Translational Research - Supporting mRNA Therapeutic Development and Beyond
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17:59Translational research cannot be conducted in a vacuum. For a translational researcher to be successful, they need to build strong relationships with individuals, companies, and institutions that will provide useful support and expertise. In this episode, Linda Mathiasson, Strategic Customer Leader for Nucleic Acid Therapeutics at Cytiva, discusses…
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Building Bridges for Translational Research - Bringing Gene Therapy Closer to the Clinic
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20:42In this episode, Guangping Gao, professor and director of the Horae Gene Therapy Center at the University of Massachusetts Medical School, speaks about developing human gene therapies using recombinant adeno-associated viral vectors, scaling up these therapies, and the future of translational research. Welcome to Building Bridges for Translational …
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Building Bridges for Translational Research - The Secrets to Start-Up Success
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18:10Welcome to Building Bridges for Translational Research, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Cytiva, a global provider of technologies and services that advance and accelerate therapeutic development, manufacturing, and delivery. To take preclinical concepts to the mar…
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Understanding the Blood Cancer Genomic Landscape
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19:49Immunotherapies are promising as a holy grail for cancer treatment, but patient responses to these interventions are often variable in both solid tumors and blood cancers. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with Olli Dufva, a physician and doctoral researcher at the University of Helsinki’s Hematology …
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Exposed: Environmental Echoes in Health - How Toxins Leave Their Cancerous Marks
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13:40Through epigenetic mechanisms, some environmental toxicants, such as heavy metals, reversibly alter gene expression patterns that then drive cancer progression. In this episode, Yvonne Fondufe-Mittendorf discusses her work studying environmental toxicants and their effects on DNA methylation and chromatin structure. Welcome to Exposed: Environmenta…
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Exposed: Environmental Echoes in Health - Are We What Our Parents Eat?
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14:19Substances that enter the body, such as food or chemicals, can make epigenetic changes in the germline that become inherited, affecting the health of future generations. In this episode, Heidi Lempradl discusses her work studying the effects of parental diet on their offspring. Welcome to Exposed: Environmental Echoes in Health, a special edition p…
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Exposed: Environmental Echoes in Health - Epigeneticist Turned Microbe Hunter
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12:08Welcome to Exposed: Environmental Echoes in Health, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Van Andel Institute, an independent biomedical research institute devoted to improving human health for generations to come. While the human body’s cells all use the same set of in…
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The New Era of Neurodegeneration Research
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16:11The brain’s intractable nature makes neurodegenerative disorders challenging to study, but modern assays and technologies give scientists a fresh look at this complex organ. In this episode, Niki Spahich from The Scientist’s Creative Services Team spoke with Erdem Gültekin Tamgüney, a professor in the Institute of Physical Biology at Heinrich Heine…
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Transporting Laboratories into the Future with Smart Technology
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14:44As smart devices become commonplace in many homes, they also enter life science laboratories with the promise to enhance productivity, simplify collaborations, and produce reliable results. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with experts from MilliporeSigma about how smart devices change research for the…
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Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
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12:14Cancer immunotherapies are saving lives, but researchers still have a long journey ahead of them. Many cancers that are initially sensitive to immunotherapy acquire resistance over time, while others are resistant from the beginning. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Stephanie Dougan, an associate …
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Hijacking Genes: Uncovering the Cause of Lineage Ambiguous Leukemia
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16:24Childhood cancer is devastating. Every year over 15,000 children in the United States are diagnosed with cancer, with leukemia accounting for 28% of all childhood cancers in children under the age of 15. Leukemia, however, is not a single class of cancer. There are numerous forms of leukemia each with its own distinct cause. In this episode, Tiffan…
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Understanding Microglial Response in Alzheimer’s Disease
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16:40A diverse population of microglial cells resides in the brain. Similar to immune cells, microglial cells respond to minute changes in their environment. Sometimes this response is beneficial and other times detrimental. Scientists are working to tease apart the dynamic role of microglial response in the pathogenesis of neurodegenerative diseases su…
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The Promise of Spatial Transcriptomics in Exploring Chronic Liver Disease
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15:19The liver performs approximately 500 separate functions in the human body. With liver disease on the rise, scientists are developing treatments to save this irreplaceable organ. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Prakash Ramachandran, a clinician scientist at the Centre for Inflammation Research at …
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Discovering the Secrets of Motor Neurons with Single Cell Sequencing
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13:50Motor neurons originating in the spine control both voluntary and involuntary movements. Even though they have an essential function, they are notoriously difficult to study. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Jacob Blum, a graduate student in Aaron Gitler’s laboratory at Stanford University, about …
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A Modern Trojan Horse: Delivering Combination Immunotherapies to Solid Tumors
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13:57Chimeric antigen receptor (CAR) T cell immunotherapies hold great promise for cancer treatment, but they are not very effective against solid tumors. Niki Spahich from The Scientist’s Creative Services team spoke with Katie McKenna, postdoctoral fellow in the laboratory of Malcolm Brenner at the Center for Cell and Gene Therapy at Baylor College of…
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Bugs with Drugs: Repurposing a Pathogenic Bacteria’s Weapon
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11:32LabTalk is a special edition podcast produced by The Scientist’s Creative Services Team, where we explore topics at the leading edge of innovative research. This episode is brought to you by Keystone Symposia. Don’t miss their upcoming virtual eSymposia Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics on May 3-4, 2…
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Predicting the Immune Response with Single-Cell Analysis: Autoimmunity, Vaccination, and COVID-19
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17:11The human immune system is highly complex and variable. Some people mount robust responses to infection, vaccination, or immunotherapy, while others fail to react appropriately. These differences have obvious implications for health and disease, and they have been especially appreciated during the COVID-19 pandemic as some individuals show no sympt…
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The Past, Present, and Future of Gene Therapy: How to Scale-up Successfully
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29:30The Scientist’s LabTalk is a special edition podcast produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research. In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Josh Snow, Director of Business Development and Marketing Strategy at Mirus Bio, about the pa…
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Halting the Tuberculosis Epidemic with Research and Diagnostics: A Conversation with David Alland
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13:10Welcome to The Scientist’s LabTalk, a special edition podcast produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research. This episode is brought to you by Keystone Symposia. Don’t miss their upcoming virtual eSymposia Tuberculosis: Science Aimed at Ending the Epidemic on December 2-4, 2020…
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Surviving Stress: The Mysteries of Neuronal Survival and Neurodegeneration
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17:49Welcome to The Scientist’s LabTalk, a special edition podcast produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research. In this episode, we explore how neurons withstand stress by looking at three cutting edge technologies: CRISPR, stem cell technology, and single-cell sequencing. Tiffany…
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Myeloid Cells in Cancer and Science Advocacy: A Conversation with Miriam Merad
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12:57Welcome to The Scientist’s LabTalk, a special edition podcast produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research. This episode is brought to you by Keystone Symposia. Don’t miss their upcoming virtual eSymposium on myeloid cells and innate immunity in solid tumors on September 21-23…
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