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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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What is the future of gene therapies? In this episode of Bioprocessing Unfiltered, host Susan D’Costa, chief technical and commercial officer of Genezen, and Phillip Ramsey, CTO of Sangamo Therapeutics, discuss a variety of topics about gene therapies, including what will transform viral vector gene therapy, the evolving role of contract development and manufacturing organizations (CDMOs), and how gene editing in general fits into the broader gene therapy landscape. Plus, they cover the three key factors that are important in a relationship with a CDMO and the onslaught of different pressures that cell and gene therapies are currently under—and how to rekindle confidence in managing that pressure and tackling challenges.
Links from this episode:
Bioprocessing Summit
Genezen
Sangamo Therapeutics
Bioprocessing Unfiltered: Covering both upstream and downstream processing, analytics, AI and digitization, cell and gene therapy and more, Bioprocessing Unfiltered is your insider’s pass to the researchers tackling—and solving—the day-to-day challenges in the bioprocessing industry.
Chapters
1. Episode: 3 - The Future of Gene Therapies and CDMOs with Philip Ramsey (00:00:00)
2. Meet The Hosts And Guest (00:00:05)
3. Career Path And Early LNP Work (00:01:01)
4. Complexity: From Bike To Jumbojet (00:03:09)
5. AAV Use Cases: Eye And Brain (00:04:18)
6. Novel Capsids And AI Design (00:07:06)
7. Redosing Hurdles And Immunity (00:08:44)
8. Manufacturing Costs And Design (00:11:21)
9. Scale Limits And Cell Lines (00:14:10)
10. Platforms, FDA, And COGS (00:16:41)
11. Insect Cells Vs Mammalian Paths (00:18:17)
12. CDMO Pressure And Partnership (00:20:08)
13. Capacity Whiplash And Strategy (00:23:18)
14. Gene Editing And CNS Delivery (00:25:56)
15. Programs, Partnerships, And AAV (00:28:22)
16. Rebuilding Confidence And Safety (00:30:40)
17. Bring Every Stakeholder To The Table (00:33:04)
18. Closing Thanks And Subscribe CTA (00:34:17)
3 episodes
