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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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📖 Read the companion Substack essay
In November 2025, the UK announced something unprecedented: a £75 million strategy to aggressively phase out animal testing—backed not primarily by ethical arguments, but by scientific evidence that the alternatives are often more accurate predictors of human outcomes. This episode unpacks three critical elements:
The Technology: Organ-on-a-chip systems smaller than credit cards, lined with human cells. 3D bioprinted tissues that function for weeks. AI analyzing millions of data points to predict drug safety in silico.
The Timeline: By end of 2026: eliminate animal testing for skin and eye irritation. By 2027: end Botox testing on mice and mandate DNA-based contamination testing. By 2030: significantly reduce pharmacokinetic studies on dogs and primates.
The Infrastructure: We explore the sophisticated balance this roadmap strikes: aggressive deadlines that create accountability, substantial funding that makes them achievable, and industry concerns about maintaining patient safety during the transition.
This isn't about choosing ethics over science. It's about recognizing that human-relevant research methods produce better predictions for human outcomes.
References:
Animal testing to be phased out faster as UK unveils roadmap for alternative methods
This is Heliox: Where Evidence Meets Empathy
Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter. Breathe Easy, we go deep and lightly surface the big ideas.
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Four recurring narratives underlie every episode: boundary dissolution, adaptive complexity, embodied knowledge, and quantum-like uncertainty. These aren’t just philosophical musings but frameworks for understanding our modern world.
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