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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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In this episode, Margaret unpacks one of the most overlooked pieces of women’s health, and that is detoxification.
She explains why perimenopause creates the “perfect storm” for toxin buildup, hormonal chaos, and inflammation, and how to support your body through this transition with practical, sustainable strategies.
From the liver-gut connection to emotional release, Margaret breaks down why detox isn’t about juice cleanses or quick fixes, but about restoring your body’s ability to process hormones, stress, and toxins efficiently. She shares actionable nutrition, mineral, and lifestyle strategies to improve energy, reduce PMS symptoms, and make your transition into menopause smoother and more empowered.
This episode is a must-listen for women in their late 30s and 40s who are feeling puffy, sluggish, or “stuck” in their health—and ready to finally understand what their body is asking for.
Episode Recap:
- What detox really means—and why it’s not about juice cleanses or saunas {01:20}
- How perimenopause slows detox pathways and raises estrogen load {04:50}
- The “perfect storm” of hormonal, liver, and stress overload during your late 30s–40s {05:40}
- Why liver and gut health determine how your hormones feel {8:53}
- Simple, functional detox support: food, minerals, bile flow, and bowel health {11:18}
- The link between nervous system regulation and hormonal balance {16:20}
- How emotions and stress block your body’s ability to detox {17:26}
- Why supporting detox now creates smoother hormones, better energy, and resilience long-term {20:46}
Links & References:
- Click here to order supplements through Fullscript
- Click here to order peptides with EllieMD, a US based telehealth provider.
- Book a peptide consult zoom call
- Download my GLP 1 Peptide Guide
- Join our 1:1 Coaching Program
- Learn more about working with our team by visiting fueledandfree.com
- Ep. 53 | Castor Oil Packs For Liver Detox, Thyroid, and Skin
- Ep. 67 | Estrogen Dominance In Perimenopause: Why You’re Bloated, Gaining Weight, Moody, & Have Heavy Periods
Connect with me on Instagram @margaretannpowell
**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.
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