Abstract: This article explores evidence-based strategies for resigning professionally from employment while preserving relationships and future opportunities. Drawing from management research, it identifies key practices for effective resignations including providing adequate notice, maintaining a positive attitude, expressing gratitude, ensuring complete work transitions, and securing positive references. The article offers practical implementation guidance with specific recommendations for resignation meetings, transition planning, and appropriate expressions of appreciation, followed by industry-specific examples demonstrating successful application across various workplace contexts. Throughout, the article emphasizes that thoughtful resignation practices benefit both departing employees and their former organizations by maintaining professional networks, enabling future collaboration, and supporting career advancement through preserved goodwill and positive references.