At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to [email protected]. Sarah Guo is a startup investor and the founder of Conviction, an investment f ...
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MATH Venture Partners Podcasts
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The TechSurge: Deep Tech VC Podcast explores the frontiers of emerging tech, venture capital, and business trends, with conversations tailored for entrepreneurs, technologists, and investment professionals. Presented by Celesta Capital, and hosted by Founding Partners Nic Brathwaite, Michael Marks, and Sriram Viswanathan. Email feedback and show ideas to [email protected]. Join us as we examine the next major tech cycle, uncover emerging global tech hubs, and analyze where VC investment d ...
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Season 4 will explore one of humanity's most rapidly advancing and impactful changes: what does it mean to be human in the age of AI when computers and robots are accomplishing more human functions? How will AI with human-level skills influence us and enhance the world around us? How will we change AI, and how will it change us? Theory and Practice opens the doors to the cutting edge of biology and computer science through conversations with leaders in the field. The podcast is hosted by Ant ...
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How to Sell on Amazon FBA with Professional Amazon FBA Sellers
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Blueprint for an AI Future: OpenAI Chief Economist on How AI Will Shape the Global Economy
52:18
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52:18Will AI displace more jobs than it creates? How can the U.S. win the AI race? How can AI benefits be evenly distributed across businesses and society? We explore these questions and more as Sriram Viswanathan sits down with Ronnie Chatterji, Chief Economist at OpenAI, for an in-depth exploration of AI's economic impact and policy implications. Ronn…
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Teaching AI to Understand the Physical World, with Dr. Fei-Fei Li of World Labs
35:53
35:53
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35:53In this episode of No Priors, Sarah and Elad are joined by Dr. Fei-Fei Li, AI pioneer, co-director of Stanford’s Human-Centered AI Institute, and founder of World Labs. Fei-Fei shares why she’s building at the intersection of embodiment and intelligence, and what today’s AI systems are still missing. From the early days of ImageNet to her vision fo…
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AI Consolidation, Biotech Opportunities, and World Models with Sarah and Elad
25:13
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25:13In this episode of No Priors, Sarah and Elad unpack the current state of the AI market - whether it’s consolidating, what’s enabling or blocking key mergers, and where the most promising untapped opportunities lie, particularly in biotech. They also explore the rise of world models and how AI’s novel methods for understanding complex systems may ul…
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Inside Nokia’s Strategy: CSTO Nishant Batra on Telecom’s Future, Brand Reinvention, and Betting on Bell Labs
47:31
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47:31In this episode of TechSurge, host Sriram Viswanathan sits down with Nishant Batra, Chief Strategy and Technology Officer at Nokia, for a deep dive into the evolving landscape of telecom and wireless technology. Nishant shares insights into the seismic shifts transforming network infrastructure—from core networks to edge computing—and discusses how…
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AI is Making Enterprise Search Relevant, with Arvind Jain of Glean
31:34
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31:34Arvind Jain joins Sarah and Elad on this episode of No Priors. Arvind is the founder and CEO of Glean, an AI-powered enterprise search platform. He previously co-founded Rubrik and spent over a decade as an engineering leader at Google. In this episode, Arvind shares how LLMs are transforming enterprise search, why most tools in the space have fail…
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Leading Through Chaos: John Chambers on Tariffs, Cyber Threats, & the AI Supercycle
39:37
39:37
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39:37Competition, growth, tariffs, hacks, AI – what does it take to be an effective leader today? John Chambers, former CEO and Executive Chairman of Cisco and founder of JC2 Ventures, joins TechSurge host Sriram Viswanathan to share valuable wisdom on leading and growing businesses through times of significant change. As a leader who has transitioned f…
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Gaming as the Future of Education with Duolingo CEO Luis von Ahn
32:14
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32:14On this episode of No Priors, Sarah talks to Luis von Ahn, founder and CEO of Duolingo, the world’s most popular education app with over 116 million monthly users and a market cap of approximately $17 billion. Controversially, it has recently committed to being “AI-first.” They discuss why motivation is the biggest challenge in education, how Duoli…
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O3 and the Next Leap in Reasoning with OpenAI’s Eric Mitchell and Brandon McKinzie
39:13
39:13
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39:13This week on No Priors, Elad and Sarah sit down with Eric Mitchell and Brandon McKinzie, two of the minds behind OpenAI’s O3 model. They discuss what makes O3 unique, including its focus on reasoning, the role of reinforcement learning, and how tool use enables more powerful interactions. The conversation explores the unification of model capabilit…
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China, Funding Cuts, & Campus Controversy: Is U.S. Tech Leadership Falling Behind?
42:07
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42:07MIT President Emeritus Dr. Rafael Reif joins host Michael Marks for a discussion about the state of U.S. competitiveness in technology, university research funding, current immigration policy, and more. Reif explains why universities remain the innovation engines of economies, educating top talent and generating the foundational research that power…
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Inside Deep Research with Isa Fulford: Building the Future of AI Agents
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30:45On this episode of No Priors, Sarah sits down with Isa Fulford, one of the masterminds behind deep research. They unpack how the initiative began, the role of human expert data, and what it takes to build agents with real-world capability and even taste. Isa shares the differences between deep research and OpenAI’s o3 model, the challenges around l…
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Predicting the Earth with Josh Goldman: How KoBold Uses AI to Find Critical Minerals
40:53
40:53
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40:53This week on No Priors, Sarah and Elad are joined by Josh Goldman, cofounder and president of KoBold Metals. KoBold is using AI to transform how we discover critical minerals like lithium and cobalt, making the exploration process faster, more precise, and more scalable than traditional methods. In this episode, Josh explains how KoBold is rethinki…
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Inside Microsoft's Trillion Dollar Playbook with Chief Strategy Officer Bobby Yerramilli-Rao
47:32
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47:32Bobby Yerramilli-Rao, Chief Strategy Officer at Microsoft, joins TechSurge host Sriram Viswanathan to offer a rare glimpse into the strategic playbook of one of the world’s most powerful tech companies. Bobby shares how the company navigates today’s biggest technology paradigm shifts, placing bets with trillion-dollar implications. Touching on Micr…
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From Job Displacement to AI Trainers, Brendan Foody on Work in the AI Age
41:52
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41:52On this episode of No Priors, Sarah and Elad sit down with Brendan Foody, CEO and cofounder of Mercor, to discuss the company’s rapid growth and their vision for the future of the labor market. They dive into how AI is reshaping the workforce in real, tangible ways and what skills are worth investing in today. Brendan shares insights on evaluating …
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Public Markets, Image Gen, and Specialized Models, with Sarah and Elad
27:44
27:44
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27:44In this episode of No Priors, Sarah and Elad examine the current state of AI. They break down the recent dip in public markets, how tariffs could impact the tech industry, and where opportunities remain in large language models. They highlight the opportunities in more specialized models, new approaches to model development, and how the market is b…
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Scaling the AI Era: Next-Gen Data Storage Solutions with Pure Storage CEO Charlie Giancarlo
59:05
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59:05In this episode of TechSurge, host Sriram Viswanathan sits down with Charlie Giancarlo, Chairman and CEO of Pure Storage, to discuss the evolution and future of data storage in the digital age. Charlie shares insights from his career spanning his pivotal role in Cisco's success as a networking pioneer, to his leadership in transforming Pure Storage…
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Conversations Are the Source of Truth in Healthcare with Abridge CEO Shiv Rao
38:42
38:42
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38:42In this episode of No Priors, Elad and Sarah chat with Shiv Rao, MD, founder and CEO of Abridge. They dive into how Abridge is reshaping healthcare by creating AI tools that enhance clinical documentation and improve doctor-patient interactions. Shiv shares his thoughts on building trust with established healthcare systems, giving agency and time b…
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The Robotics Revolution, with Physical Intelligence’s Cofounder Chelsea Finn
35:14
35:14
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35:14This week on No Priors, Elad speaks with Chelsea Finn, cofounder of Physical Intelligence and currently Associate Professor at Stanford, leading the Intelligence through Learning and Interaction Lab. They dive into how robots learn, the challenges of training AI models for the physical world, and the importance of diverse data in reaching generaliz…
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Many in venture capital and biopharma are anointing artificial intelligence the savior of drug discovery—but what can AI actually do? In this eye-opening episode, Michael Marks sits down with Mike Nohaile, CEO of Prellis Biologics, to explore the hype versus reality in AI-enabled drug discovery. Mike details why, despite significant breakthroughs l…
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Copilot, Agent Mode, and the New World of Dev Tools with GitHub’s CEO Thomas Dohmke
50:34
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50:34This week on No Priors, Sarah and Elad talk with GitHub CEO Thomas Dohmke about the rise of AI-powered software development and the success of Copilot. They discuss how Copilot is reshaping the developer workflow, GitHub’s new Agent Mode, and competition in the developer tooling market. They also explore how AI-driven coding impacts software pricin…
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National Security Strategy and AI Evals on the Eve of Superintelligence with Dan Hendrycks
36:24
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36:24This week on No Priors, Sarah is joined by Dan Hendrycks, director of the Center of AI Safety. Dan serves as an advisor to xAI and Scale AI. He is a longtime AI researcher, publisher of interesting AI evals such as "Humanity's Last Exam," and co-author of a new paper on National Security "Superintelligence Strategy" along with Scale founder-CEO Ale…
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Understanding the Elegant Math Behind Modern Machine Learning
1:14:43
1:14:43
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1:14:43Artificial intelligence is evolving at an unprecedented pace—what does that mean for the future of technology, venture capital, business, and even our understanding of ourselves? Award-winning journalist and writer Anil Ananthaswamy joins us for our latest episode to discuss his latest book Why Machines Learn: The Elegant Math Behind Modern AI. Ani…
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Building the Platform for Scientific Breakthrough, with Noubar Afeyan of Moderna and Flagship Pioneering
40:32
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40:32This week on No Priors, Sarah sits down with Noubar Afeyan, Co-founder and CEO of Flagship Pioneering, the biotech firm behind groundbreaking companies like Moderna. They explore how Flagship creates the conditions for scientific breakthroughs, tackles regulatory uncertainty, and pushes the boundaries of discovery. Noubar shares insights on AI’s ro…
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Virtual Cell Models, Tahoe-100 and Data for AI-in-Bio with Vevo Therapeutics and the Arc Institute
57:40
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57:40On this week’s episode of No Priors, Sarah Guo is joined by leading members of the teams at Vevo Therapeutics and the Arc Institute – Nima Alidoust, CEO/Co-Founder at Vevo Therapeutics; Johnny Yu, CSO/Co-Founder at Vevo Therapeutics; Patrick Hsu, CEO/Co-Founder at Arc Institute; Dave Burke, CTO at Arc Institute; and Hani Goodarzi, Core Investigator…
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Building Hard Tech in Hard Markets: Kyle Vogt on Cruise, Twitch, and The Bot Company
38:14
38:14
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38:14Kyle Vogt joins Sarah and Elad on this week’s episode of No Priors. A serial entrepreneur, Kyle co-founded Twitch, transforming live streaming, and later Cruise, the autonomous vehicle company acquired by GM for $1 billion. Now he’s taking on AI-powered home robotics with The Bot Company. In this episode, Kyle shares his journey building transforma…
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How Harvey AI is Changing the Legal Industry with Winston Weinberg
49:35
49:35
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49:35This week on No Priors, Sarah sits down with Harvey cofounder and CEO Winston Weinberg. Harvey is one of the leading application layer AI companies, building domain-specific AI for law firms, professional service providers, and the Fortune 500. They are already working with companies like Bridgewater, KKR, PWC, and O’Melveny with over $500M in fund…
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21st Century Warfare: The Nexus of Technology, Economy, & National Security
45:22
45:22
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45:22With global economic alliances shifting and new threats emerging, will the U.S. maintain its dominance in an increasingly complex world? From chips to cyberterrorist threats to cryptocurrency, battles for global dominance are no longer only fought on the battlefield—they're playing out in markets, boardrooms, and cyberspace. In this episode, we sit…
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DeepSeek, Deep Research, and 2025 Predictions with Sarah and Elad
22:32
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22:32This week on No Priors, Sarah and Elad celebrate the 100th episode! They dive into the biggest AI stories of 2025, breaking down DeepSeek—truth vs. hype, the rapid consumer adoption, and the real cost of training the models. They debate model commoditization and the value of being a frontier model provider vs. building on existing work. Plus, they …
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Rick Caruso on LA’s Wildfires, Policy Failures, and the Path Forward
27:11
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27:11This week on No Priors, Elad sits down with Rick Caruso, LA real estate developer and runner-up in the 2022 mayoral race. With experience serving under three LA mayors, as well as on the police commission and the board of water and power, Rick offers a unique perspective on the systemic failures that contributed to the devastation of the January 20…
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Adapting to AI & Geopolitical Disruption with Global Head of McKinsey Bob Sternfels
50:37
50:37
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50:37The world is evolving faster than ever – how will we keep up? From AI breakthroughs to global supply chain disruptions, the forces shaping business and technology today are relentless. In this episode of the TechSurge Deep Tech VC Podcast, we sit down with Bob Sternfels, Global Managing Partner of McKinsey & Company, the global consulting firm who …
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What Can We Do About Wildfires? With Convective Capital’s Bill Clerico
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37:59This week on No Priors, Sarah and Elad sit down with Bill Clerico, founder of Convective Capital, an early stage venture fund focused on technology-driven solutions for wildfire mitigation and climate resilience. The wildfires in Los Angeles have caused unprecedented property damage and immense hardship for countless individuals and families. This …
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The Future of Wireless, Academia, & Intel: A Conversation With Dr. Andrea Goldsmith
53:16
53:16
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53:16The future of wireless technology is unfolding, are you ready for what's next? How can Intel regain market dominance? How will AI and IOT shape the next generation of wireless? What are the challenges in transitioning to 5G, NextG, and beyond? How will academia and the startup world intersect in the 21st century economy? We explore these questions …
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How AI Agents Are Transforming Customer Support, with Decagon’s Jesse Zhang
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30:09Today on No Priors, co-founder and CEO of Decagon, Jesse Zhang, joins Elad to discuss the future of agentic customer support. Decagon provides AI-powered customer interactions for companies like Rippling, Notion, Duolingo, Classpass, Substack, Vanta, Eventbrite, and more. Jesse shares the thesis behind starting Decagon, why he sees customer support…
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Erik Bernhardsson on Creating Tools That Make AI Feel Effortless
23:36
23:36
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23:36Today on No Priors, Elad chats with Erik Bernhardsson, founder and CEO of Modal Labs, a platform simplifying ML workflows by providing a serverless infrastructure designed to streamline deployment, scaling, and development for AI engineers. Erik talks about his early work on Spotify’s ML algorithms, what Modal offers today, and his vision for build…
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The Best of 2024 with Sarah Guo and Elad Gil
27:07
27:07
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27:072024 has been a year of transformative technological progress, marked by conversations that have reshaped our understanding of AI's evolution and what lies ahead. Throughout the year, Sarah and Elad have had the privilege of speaking with some of the brightest minds in the field. As we look back on the past months, we’re excited to share highlights…
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Revolutionizing Customer Success with Agency’s Elias Torres
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31:18Today on No Priors, Sarah sits down with Elias Torres, CEO and founder of Agency, an AI agent for customer success teams. Elias shares his journey from growing up in Nicaragua to founding several companies, leading engineering at HubSpot, and selling Drift for $1B. He also discusses his work consulting with OpenAI in 2022, which deepened his unders…
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How AI Is Fueling the Transformation of Medical Imaging
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46:20In this episode, host Michael Marks dives into the transformative role of artificial intelligence in healthcare. Michael is joined by Dr. Alex Sardiña of WhiteRabbit.ai and Kalyan Sivasilam of 5C Network, two early adopters bringing AI to medicine through sharply contrasting market models in the U.S. and India, respectively. The discussion unpacks …
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How Diamond Cooling Could Power the Future of AI, with Akash Systems
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42:21In this episode of No Priors, Sarah sits down with Felix Ejeckam and Ty Mitchell, founders of Akash Systems, a company pioneering diamond-based cooling technology for semiconductors used in space applications and large-scale AI data centers. Felix and Ty discuss how their backgrounds in materials science led them to tackle one of the most pressing …
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Bolt’s Eric Simons on Enabling Everyone to Generate Websites with AI
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38:17In this episode of No Priors, Sarah talks with Eric Simons, co-founder and CEO of StackBlitz. The company has experienced explosive growth since the launch 2 months ago of Bolt.new, an AI application that lets users prompt, run, edit, and deploy full-stack applications directly in the browser. Eric talks about the years-long journey that led to ove…
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