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The Mightiest Warriors is a podcast that shines light on the remarkable stories of humans who have transformed profound adversity in their lives into a force of compassion, leadership and service to others. "He who has a why to live for can deal with almost any how." Victor Frankl
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The Health Edge: translating the science of self-care

Mark Pettus MD and John Bagnulo PhD, MPH

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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”. Will Rogers We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from t ...
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Send us a text What happens when a tennis prodigy hits rock bottom at 19, only to discover an inner strength that transforms not just his game, but eventually the science of nutrition, fitness and human performance? Dr. Paul Arciero takes us on his remarkable journey from struggling student to pioneering protein metabolism researcher whose work is …
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Send us a text Dr. Allison Brager lives at the fascinating intersection of elite athletics, military service, and cutting-edge neuroscience. As one of the Army's "71 Foxes" - a small, specialized group of uniformed neuroscientists and neuropsychologists- she's revolutionizing how we understand human performance in extreme conditions. This conversat…
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Send us a text Nature deficit syndrome is silently affecting millions as we spend over 95% of our lives indoors beneath artificial lighting that disrupts our biology at the most fundamental level. Dr. Mark Pettus delivers a compelling exploration of this modern disconnection, introducing the powerful concept that our current "junk light" epidemic m…
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Send us a text At a time when anxiety and depression rates are soaring across all age groups, Dr. Mark Pettus cuts through the noise with revelatory insights into how our daily choices shape our mental landscape. This compelling exploration connects the dots between what's on your plate, how you move through your day, and the remarkable resilience …
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Send us a text When the mountains meet the sea in Kodiak, Alaska, something transformative happens to those who embrace its challenges. Retired Navy SEAL Captain Casey Harver discovered this power during military training and never looked back, eventually establishing Kodiak Big Timber and the Kodiak Survival School to share these life-changing exp…
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Send us a text The rhythms of nature have orchestrated human biology for millennia, but our modern lifestyle has disconnected us from these essential patterns. Dr. Mark Pettus takes us on a fascinating journey through the science of circadian rhythms, revealing how light serves as crucial information that synchronizes every cell in our bodies with …
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Send us a text Curious about natural alternatives to expensive GLP-1 medications like Ozempic? Dr. Mark Pettus unveils powerful nutritional strategies to boost your body's own GLP-1 production for improved metabolic health and sustainable weight management. This eye-opening presentation dives into the fascinating relationship between your diet, gut…
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Send us a text Michael "Rod" Rodriguez's life reads like an epic American saga—a generational story of service spanning from his grandfathers to his son. As a Green Beret with ten combat deployments behind him, Rod now leads the Global War on Terrorism Memorial Foundation with the same fierce dedication that characterized his military career. When …
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Send us a text Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as "the cause of everything" and introduces the concept of "inflammaging" – how chronic inflammation accelerate…
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Send us a text Prepare to have your understanding of genetics completely transformed. The revolutionary science of epigenetics reveals that you're not simply a prisoner of your DNA – you're actively participating in how your genes express themselves through every choice you make. Dr. Mark Pettus takes us on a fascinating journey through this emergi…
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Send us a text The debut episode of The Mightiest Warriors podcast takes listeners on a deeply personal journey through host Dr. Mark Pettus' remarkable life story—one that embodies the podcast's mission of highlighting how ordinary people transform profound adversity into extraordinary service. Dr. Pettus, Medical Director of Essential Provisions,…
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Send us a text Creatine might be the most underappreciated nutritional powerhouse in our health toolkit. While many associate it exclusively with weightlifters and athletes, the science reveals a molecule with profound benefits reaching far beyond the gym. Mark Pettus MD and John Bagnulo PhD,MPH dive into creatine's fundamental role in human physio…
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Send us a text Unlock the secrets to a healthier, longer life by mastering the science behind protein intake. Discover the critical role of animal protein in maintaining lean body mass, boosting metabolic health, and combating age-related muscle loss. We challenge traditional views and outdated guidelines, bringing you insights from recent research…
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Send us a text In this first Health Edge podcast of 2025, Mark Pettus MD and John Bagnulo PhD, MPH review a 2024 study published in The Journal of Nutrition. https://www.sciencedirect.com/science/article/abs/pii/S002231662400289X?via%3Dihub https://www.thehealthedgepodcast.comBy Mark Pettus MD and John Bagnulo PhD, MPH
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Send us a text In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of li…
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Send us a text In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention. JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022. https://pubmed.ncbi.nlm.nih.gov/…
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Send us a text Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadeca…
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Send us a text In a world where health advice is abundant, it can be challenging to sift through conflicting data and headlines. One such contentious issue is the connection between red meat and type 2 diabetes. On this episode of The Health Edge, we take a critical look at this connection and aim to provide a balanced perspective on this often pol…
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Send us a text Ready to have your understanding of BMI flipped on its head? We're diving into an intriguing study that suggests a BMI lower than 25 might be linked with decreased mortality. That's right, what you've been told about the ideal BMI could be all wrong. We also tackle the waist to hip ratio, showing you how to measure it and why it migh…
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Send us a text Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference int…
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Send us a text In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downlo…
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Send us a text In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigen…
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Reeves Price has seen Hangout Music Fest from both sides, first as a fan for years and now as producer and vice president festivals for AEG Presents. He talks about the Gulf Shores music festival and what to expect this year.By From Business Alabama magazine
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Send us a text In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk. Papers referenced: https://www.nature.com/articles/s4159... https://bmjopen.bmj.com/content/6/6/e... https://www.ncbi.nlm.nih.…
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Send us a text In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall …
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Send us a text This is a replay of a prior podcast examining the relationship between sodium and hypertension. A growing body of research suggests there is a point below which e.g. 3,000 mg/day where risk is increased. This recording is a prelude to our upcoming podcast on sodium restriction and insulin resistance.…
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Send us a text In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective. https://www.nature.com/articles/s41591-023-02223-9 Another recent review of risks and…
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Dr. Michael Chambers, associate vice president of research and economic development at the University of South Alabama and board member of Innovate Alabama, talks about research at USA and Innovate Alabama's second round of funding.By From Business Alabama magazine
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Send us a text In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater ris…
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Send us a text Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals…
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