Can RNA drugs solve the obesity epidemic?

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Resalis Therapeutics is pursuing a groundbreaking approach to obesity treatment.

Unlike current therapies that primarily focus on appetite suppression, Resalis’ lead program, RES-010, is a non-coding RNA drug candidate that targets underlying biological pathways to promote sustainable weight loss.

By enhancing energy expenditure through white-to-brown adipose tissue conversion while preserving muscle mass, RES-010 is positioned as an ideal standalone therapy or a synergistic option for long-term weight management.

The company recently initiated a phase 1 study in December 2024 for RES-010 in healthy and obese subjects, and they also secured an equity investment from Sanofi in October 2024.

To talk about ways to tackle obesity, and Resalis’ approach, our guest on the podcast this week is Alessandro Toniolo, CEO of Resalis Therapeutics.

00:57-05:06: About Resalis Therapeutics
05:06-08:59: Issues of obesity
08:59-13:20: Companies working on obesity treatments
13:20-15:34: Does suppressing appetite affect nutrition?
15:34-17:49: Introduction of new obesity treatments
17:49-21:33: Approaches other than appetite suppression
21:33-22:38: RES-010 mode of action
22:38-24:04: Administration methods
24:04-25:11: Clinical trials
25:11-26:38: Resalis’ pipeline
26:38-28:08: Next steps for Resalis
28:08-28:36: Effect of obesity on other parts of the body
28:36-29:06: Final comments
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Chapters

1. Can RNA drugs solve the obesity epidemic? (00:00:00)

2. About Resalis Therapeutics (00:00:57)

3. Issues of obesity (00:05:06)

4. Companies working on obesity treatments  (00:08:59)

5. Does suppressing appetite affect nutrition ? (00:13:20)

6. Introduction of new obesity treatments  (00:15:34)

7. Approaches other than appetite suppression  (00:17:49)

8. RES-010 mode of action  (00:21:33)

9. Administration methods  (00:22:38)

10. Clinical trials  (00:24:04)

11. Resalis’ pipeline  (00:25:11)

12. Next steps for Resalis  (00:26:38)

13. Effect of obesity on other parts of the body  (00:28:08)

14. Final comments (00:28:36)

146 episodes

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