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Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
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The Latest Evidence on Targeting B7-H3 in Small Cell Lung Cancer

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Manage episode 478843117 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

In this episode, hear Lauren Byers, MD and Christine Hann, MD share their insights on the latest data regarding new therapies targeting B7-H3 in small cell lung cancer including:

  • Rationale for targeting B7-H3
  • Overview of the structure of antibody-drug conjugates (ADCs)
  • Results from the phase I/II IDeate-PanTumor01 trial of ifinatamab deruxtecan (I-DXd) in ES-SCLC
  • Data from the phase II IDeate-Lung02 trial of 2 different doses of I-DXd in patients with previously treated ES-SCLC
  • An overview of the ongoing phase III trials IDeate-Lung02 and IDeate-Lung03 of I-DXd in SCLC
  • Early phase evidence on other novel B7-H3 ADCs including YL201 and HS-20093

Program faculty:

Lauren Byers, MD
Professor and Thoracic Section Chief
Department of Thoracic/Head and Neck Medical Oncology
MD Anderson Cancer Center
Houston, Texas

Christine L. Hann, MD, PhD
Associate Professor of Oncology
Director, Small Cell Lung Cancer Therapeutics
Johns Hopkins University School of Medicine
Baltimore, Maryland

  continue reading

192 episodes

Artwork
iconShare
 
Manage episode 478843117 series 3256997
Content provided by Clinical Care Options, LLC and Clinical Care Options. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Clinical Care Options, LLC and Clinical Care Options or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

In this episode, hear Lauren Byers, MD and Christine Hann, MD share their insights on the latest data regarding new therapies targeting B7-H3 in small cell lung cancer including:

  • Rationale for targeting B7-H3
  • Overview of the structure of antibody-drug conjugates (ADCs)
  • Results from the phase I/II IDeate-PanTumor01 trial of ifinatamab deruxtecan (I-DXd) in ES-SCLC
  • Data from the phase II IDeate-Lung02 trial of 2 different doses of I-DXd in patients with previously treated ES-SCLC
  • An overview of the ongoing phase III trials IDeate-Lung02 and IDeate-Lung03 of I-DXd in SCLC
  • Early phase evidence on other novel B7-H3 ADCs including YL201 and HS-20093

Program faculty:

Lauren Byers, MD
Professor and Thoracic Section Chief
Department of Thoracic/Head and Neck Medical Oncology
MD Anderson Cancer Center
Houston, Texas

Christine L. Hann, MD, PhD
Associate Professor of Oncology
Director, Small Cell Lung Cancer Therapeutics
Johns Hopkins University School of Medicine
Baltimore, Maryland

  continue reading

192 episodes

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