Dr. Mark D. Hill is a professor emeritus of computer sciences at the University of Wisconsin Madison, and currently a Partner Hardware Architect with Microsoft Azure. He has made numerous contributions to parallel computer system design, memory system design, computer simulation, and more. He is well known for his advice and collaborative work style, having published papers with 160 different co-authors. He talks to us about cross-layer optimizations, impactful collaborations, and visioning for computer architecture research.