Here we review ashwagandha a nutritional supplement that has plausible mechanisms for slowing ALS, promising pre-clinical evidence, and a reasonable safety profile. There is one person with ALS who experienced a reversal of symptoms on a cocktail of treatments that included ashwagandha. Cases like this are difficult to interpret as there can be multiple explanations for a person experiencing an ALS reversal. We have not found any other cases suggesting improvement on this product. We hope to see the data from the completed phase 2 trial soon.