Facing the tough decisions of a serious health threat brings the need for information and analysis into a sharp and personal focus. Computer scientist Regina Barzilay was an expert in natural language processing when she joined MIT; her cancer diagnosis led her to collaborations in healthcare, where she has advanced imaging, prediction, drug discovery, and clinical AI. She joins Munther Dahleh and Liberty Vittert to talk about issues from data collection and privacy to bias and “distributional shift” – when an algorithm is used on a dataset with key differences from the data used to train it.