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🔬 New paradigm for HFpEF! 🧠 The Adipokine Hypothesis reframes preserved EF heart failure as an endocrine disorder driven by dysfunctional visceral fat. 🫀

Adipokines like leptin, aldosterone & neprilysin disrupt volume, inflammation & fibrosis. Target the fat ➡️ fix the heart! 💡

📄 JACC 2025 | Milton Packer MD

#HFpEF #Cardiology #Adipokines #VisceralFat #Obesity #HeartFailure

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