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Inflammation ๐ฅ, Dopamine ๐, and Apathy ๐: A Neuroimmune Pathway in Brain Fog?
Manage episode 477731669 series 2740117
Cancer cachexia isnโt just weight lossโitโs a hijacking of motivation ๐. Elevated IL-6 ๐ฅ activates a brainstem-to-basal ganglia circuit ๐ง that suppresses dopamine ๐ in the nucleus accumbens, leading to effort-based apathy ๐ค.
Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway ๐ก.
416 episodes
Manage episode 477731669 series 2740117
Cancer cachexia isnโt just weight lossโitโs a hijacking of motivation ๐. Elevated IL-6 ๐ฅ activates a brainstem-to-basal ganglia circuit ๐ง that suppresses dopamine ๐ in the nucleus accumbens, leading to effort-based apathy ๐ค.
Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway ๐ก.
416 episodes
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