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Inflammation ๐Ÿ”ฅ, Dopamine ๐Ÿ’Š, and Apathy ๐Ÿ˜: A Neuroimmune Pathway in Brain Fog?

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Manage episode 477731669 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

Cancer cachexia isnโ€™t just weight lossโ€”itโ€™s a hijacking of motivation ๐Ÿ˜”. Elevated IL-6 ๐Ÿ”ฅ activates a brainstem-to-basal ganglia circuit ๐Ÿง  that suppresses dopamine ๐Ÿ’Š in the nucleus accumbens, leading to effort-based apathy ๐Ÿ’ค.

Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway ๐Ÿ’ก.

  continue reading

416 episodes

Artwork
iconShare
 
Manage episode 477731669 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

Cancer cachexia isnโ€™t just weight lossโ€”itโ€™s a hijacking of motivation ๐Ÿ˜”. Elevated IL-6 ๐Ÿ”ฅ activates a brainstem-to-basal ganglia circuit ๐Ÿง  that suppresses dopamine ๐Ÿ’Š in the nucleus accumbens, leading to effort-based apathy ๐Ÿ’ค.

Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway ๐Ÿ’ก.

  continue reading

416 episodes

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