Artwork
iconShare
 
Manage episode 515588185 series 2740117
Content provided by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC, Dr RR Baliga, MD, and MBA or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

🧓 Aging skin, fading flow. This 2025 Nature study uncovers how dermal capillary-associated macrophages (CAMs) decline with age—preceding microvascular dysfunction and impaired blood flow.

🧬 Using intravital imaging and macrophage fate mapping in mice (and validating in humans!), the authors reveal that CAMs are not replenished unless triggered by injury or CSF1. 🛠️ Fascinatingly, local CSF1–Fc therapy restored CAMs and rejuvenated perfusion in aged skin. A compelling case for targeting tissue-resident immunity! 🩸

📖 doi:10.1038/s41586-025-09639-y

  continue reading

772 episodes