In this deeply candid conversation, journalist and author Jon Gluck recounts his 22-year journey living with multiple myeloma, an incurable but treatable bone-marrow cancer. He describes the shock of his diagnosis at age 38 and the long, winding road of tests, remissions, relapses, and emerging treatments that have kept him alive. The discussion explores how Gluck navigates profound uncertainty, the illusion of control, and the emotional toll that chronic illness places not only on the patient but also on family and relationships. He and his wife confronted the strain of living in medical limbo, ultimately turning to therapy to rebuild connection during what he calls becoming "cancer zombies."

The conversation also highlights the restorative role of fly fishing, which Gluck describes as one of the few activities capable of placing him entirely in the present. This genuine flow state quiets fear and anxiety. He shares broader lessons about empathy, how to speak to someone with a serious diagnosis, and the importance of intentionally pursuing joy, connection, and meaning while living alongside uncertainty.

The heart of the discussion is Jon's insight into living meaningfully in the face of uncertainty. His story shows that while we cannot control the inevitabilities of illness or life's unpredictability, we can control how we show up—seeking information, accepting our limits, nurturing relationships, and embracing activities that restore us. His emphasis on intentionally choosing joy, connection, and presence—even in the shadow of chronic illness—offers a universal lesson for anyone facing their own uncertainties.

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