Jesus prepared his disciples for the harsh realities of kingdom mission, warning them they would face opposition like sheep among wolves. He instructed them to be shrewd as serpents yet harmless as doves, combining wisdom with innocence. When facing trials, God would provide the right words through His Spirit. Jesus warned that even families might turn against them, as the kingdom exposes divided loyalties. The key is enduring through continued mission work rather than mere survival, knowing when to move on from unfruitful opposition while trusting God's timing and provision.