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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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The FDA has updated its stance on estrogen therapy, reversing decades of confusion from early WHI interpretations. New research and global data now show estrogen may support long-term health and reduce key chronic risks.
This episode explains the FDA’s updated guidance, what the WHI got wrong, and what current science reveals about heart health, brain function, diabetes risk, bone density, and breast cancer. We also break down synthetic progestins vs. bioidentical progesterone, why timing matters, and how Europe achieved better outcomes with HRT.
Tune in to get clear, evidence-based insights so you can talk confidently with your provider and decide if hormone therapy fits your goals.
Timestamps:
00:00 FDA Update
00:27 WHI Misinterpretation
01:05 Synthetic vs Bioidentical
02:14 Why Estrogen Was Blamed
03:12 Black Box Warning
04:48 New Research
06:10 Heart/Brain/Cancer Data
07:45 Europe’s Approach
08:30 Progestins vs Progesterone
09:45 What It Means Today
10:45 Why Doctors Stopped HRT
11:30 FDA 2025 Review
12:28 Black Box Removal
13:25 Key Takeaways
14:05 How to Discuss HRT
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