“Regenerative medicine” often brings to mind the high-tech world of stem cells and tissue engineering. In this KER Cast, Dr. Ian Hargraves, a designer and shared decision making researcher at Mayo Clinic, joins Dr. Victor Montori to outline a novel conceptualization of “regenerative” care: one that shifts the focus from restoration of the body itself to the regeneration of patients’ lives, capacities, environments, and relationships. Join Drs. Montori and Hargraves in this sweeping discussion of human-centered design, pipe organ building, and the underlying philosophy of “people matter” that drives Dr. Hargraves’ in his work.