This episode reviews information from Dr. Ryan Flannigan, a urologist specializing in reproductive and sexual medicine, and provides a comprehensive overview of penile injection therapy for erectile dysfunction. He details what the treatment entails, including common medications like Trimix and Bimix, and how it works by locally stimulating blood flow and muscle relaxation within the penis. The video outlines reasons for considering this therapy, such as failure of other treatments or nerve damage from prostate cancer, alongside contraindications like dexterity issues or bleeding disorders. A significant portion of the video is dedicated to a step-by-step guide on performing the injection safely, from preparing the medication and the injection site to delivering the dose. Finally, Dr. Flannigan addresses the critical risk of priapism (prolonged erection), explaining its dangers and providing detailed instructions on prevention and management, including when to seek emergency medical attention.