Interviews with mathematics education researchers about recent studies. Hosted by Samuel Otten, University of Missouri. www.mathedpodcast.com Produced by Fibre Studios
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143: Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease
Manage episode 488506366 series 3340456
Content provided by NeurologyLive® Mind Moments®. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by NeurologyLive® Mind Moments® or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.
In this episode, "Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease" Rajesh Pahwa, MD, director of the Parkinson’s Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD). Pahwa explains the rationale behind cell replacement therapy as a means to restore dopamine production, outlining the progression from fetal tissue implants to stem cell–derived dopaminergic neurons. He details key elements of the study design, including patient selection criteria, trial endpoints, and long-term goals. Reflecting on decades of research in this space, he emphasizes the potential impact of a one-time, hardware-free surgical option and how this novel approach could complement or shift the current treatment landscape. While many questions remain, Pahwa highlights the promise of bemdaneprocel as a next-generation option in Parkinson care.
Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page.
Episode Breakdown:
In this episode, "Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease" Rajesh Pahwa, MD, director of the Parkinson’s Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD). Pahwa explains the rationale behind cell replacement therapy as a means to restore dopamine production, outlining the progression from fetal tissue implants to stem cell–derived dopaminergic neurons. He details key elements of the study design, including patient selection criteria, trial endpoints, and long-term goals. Reflecting on decades of research in this space, he emphasizes the potential impact of a one-time, hardware-free surgical option and how this novel approach could complement or shift the current treatment landscape. While many questions remain, Pahwa highlights the promise of bemdaneprocel as a next-generation option in Parkinson care.
Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page.
Episode Breakdown:
- 1:00 – Mechanism and rationale behind bemdaneprocel as a dopaminergic cell therapy
- 3:00– Key design considerations for conducting a registrational phase 3 cell therapy trial
- 5:25 – Trial structure, eligibility criteria, and ongoing patient recruitment
- 6:35 – Neurology News Minute
- 8:45 – Significance of reaching phase 3 with a cell therapy in Parkinson disease
- 10:20 – Future role of cell therapy within the Parkinson disease treatment landscape
- 12:10 – Unique aspects of the exPDite-2 trial and what sets it apart from earlier efforts
The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:
BTK Inhibitor Fenebrutinib Demonstrates Long-Term Suppression of MS Activity in Open-Label Extension
REGENXBIO Reports Positive Phase 1/2 Data for Higher Dose of RGX-202 in Duchenne Muscular Dystrophy
NewAmsterdam Pharma Reports Positive Topline Data of Alzheimer Agent Obicetrapib from Phase 3 BROADWAY Trial
Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
161 episodes
Share
Manage episode 488506366 series 3340456
Content provided by NeurologyLive® Mind Moments®. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by NeurologyLive® Mind Moments® or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.
In this episode, "Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease" Rajesh Pahwa, MD, director of the Parkinson’s Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD). Pahwa explains the rationale behind cell replacement therapy as a means to restore dopamine production, outlining the progression from fetal tissue implants to stem cell–derived dopaminergic neurons. He details key elements of the study design, including patient selection criteria, trial endpoints, and long-term goals. Reflecting on decades of research in this space, he emphasizes the potential impact of a one-time, hardware-free surgical option and how this novel approach could complement or shift the current treatment landscape. While many questions remain, Pahwa highlights the promise of bemdaneprocel as a next-generation option in Parkinson care.
Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page.
Episode Breakdown:
In this episode, "Bemdaneprocel and the Future of Cell Therapy in Parkinson Disease" Rajesh Pahwa, MD, director of the Parkinson’s Disease and Movement Disorder Center at the University of Kansas Medical Center, discusses the phase 3 exPDite-2 trial evaluating bemdaneprocel, an investigational cell therapy for Parkinson disease (PD). Pahwa explains the rationale behind cell replacement therapy as a means to restore dopamine production, outlining the progression from fetal tissue implants to stem cell–derived dopaminergic neurons. He details key elements of the study design, including patient selection criteria, trial endpoints, and long-term goals. Reflecting on decades of research in this space, he emphasizes the potential impact of a one-time, hardware-free surgical option and how this novel approach could complement or shift the current treatment landscape. While many questions remain, Pahwa highlights the promise of bemdaneprocel as a next-generation option in Parkinson care.
Looking for more Movement disorder discussion? Check out the NeurologyLive® Movement disorder clinical focus page.
Episode Breakdown:
- 1:00 – Mechanism and rationale behind bemdaneprocel as a dopaminergic cell therapy
- 3:00– Key design considerations for conducting a registrational phase 3 cell therapy trial
- 5:25 – Trial structure, eligibility criteria, and ongoing patient recruitment
- 6:35 – Neurology News Minute
- 8:45 – Significance of reaching phase 3 with a cell therapy in Parkinson disease
- 10:20 – Future role of cell therapy within the Parkinson disease treatment landscape
- 12:10 – Unique aspects of the exPDite-2 trial and what sets it apart from earlier efforts
The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:
BTK Inhibitor Fenebrutinib Demonstrates Long-Term Suppression of MS Activity in Open-Label Extension
REGENXBIO Reports Positive Phase 1/2 Data for Higher Dose of RGX-202 in Duchenne Muscular Dystrophy
NewAmsterdam Pharma Reports Positive Topline Data of Alzheimer Agent Obicetrapib from Phase 3 BROADWAY Trial
Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
161 episodes
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Similar to NeurologyLive® Mind Moments®
Interviews with mathematics education researchers about recent studies. Hosted by Samuel Otten, University of Missouri. www.mathedpodcast.com Produced by Fibre Studios
…
continue reading
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…
continue reading
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continue reading
Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
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continue reading
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…
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The Aubrey Marcus Podcast is a destination for honest and vulnerable conversations about the deeper questions in life. The show blends humor with gravity and levity with depth, as we explore mindset, psychedelics, holistic health, spirituality, entrepreneurship, and relationship. Aubrey Marcus is the founder of the globally disruptive human optimization brand Onnit, the donation based coaching platform Fit For Service, and is the New York Times bestselling author of Own the Day, Own your Lif ...
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