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Content provided by Regina Nuzzo and Kristin Sainani. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Regina Nuzzo and Kristin Sainani or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.

Does a little alcohol really make you speak a foreign language better? This week we unpack a quirky randomized trial that tested Dutch pronunciation after a modest buzz—and came to the opposite conclusion the researchers expected. We use it as the perfect holiday case study: instead of arguing with Uncle Joe at the dinner table, we’ll show you how to pull apart a scientific headline using a friendly, practical checklist anyone can learn. Along the way we stress-test the study’s claims, take a quick detour into what a .04% buzz actually looks like, and run our own before-and-after experiment with two brave science journalists at the ScienceWriters2025 conference in Chicago. A holiday survival guide with vodka tonics, statistical sleuthing, and a few surprisingly smooth French phrases.

Statistical topics

  • Alternative explanations
  • Arithmetic consistency / GRIM test
  • Blinding
  • Effect size / magnitude
  • Generalizability / external validity
  • Observational studies vs. experiments
  • Outcome measurement
  • PICOT framework
  • Placebo and expectancy effects
  • Primary outcomes / pre-specification
  • Randomized controlled trials
  • Research hypotheses
  • Sample size
  • SMART framework
  • Statistical significance (signal vs. noise)
  • Transparency and trustworthiness

Methodological morals

  • “​​You don't need a PhD to read a study. Just remember, PICOT and SMART.”
  • “A decimal point can mean the difference between life and death. Details matter.”

References

Kristin and Regina’s online courses:

Demystifying Data: A Modern Approach to Statistical Understanding

Clinical Trials: Design, Strategy, and Analysis

Medical Statistics Certificate Program

Writing in the Sciences

Epidemiology and Clinical Research Graduate Certificate Program

Programs that we teach in:

Epidemiology and Clinical Research Graduate Certificate Program

Find us on:

Kristin - LinkedIn & Twitter/X

Regina - LinkedIn & ReginaNuzzo.com

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22 episodes