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When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
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It’s our first stats reunion! In this special review episode, we revisit favorite concepts from past episodes—p-values, multiple testing, regression adjustment—and give them fresh personalities as characters. Meet the seductive false positive, the clingy post hoc ex, and Charlotte, the well-meaning but overfitting idealist.
Statistical topics
- Bar charts vs Box plots
- Bonferroni correction
- Confounding
- False positives
- Multiple testing
- Multivariable regression
- Outcome switching
- Over-adjustment
- Post hoc analysis
- Pre-registration
- Residual confounding
- Statistical adjustment using regression
- Subgroup analysis
- Unmeasured confounding
References
- Nuzzo RL. The Box Plots Alternative for Visualizing Quantitative Data. PM R. 2016 Mar;8(3):268-72. doi: 10.1016/j.pmrj.2016.02.001. Epub 2016 Feb 15. PMID: 26892802.
- Sainani KL. The problem of multiple testing. PM R. 2009 Dec;1(12):1098-103. doi: 10.1016/j.pmrj.2009.10.004. PMID: 20006317.
Kristin and Regina’s online courses:
Demystifying Data: A Modern Approach to Statistical Understanding
Clinical Trials: Design, Strategy, and Analysis
Medical Statistics Certificate Program
Epidemiology and Clinical Research Graduate Certificate Program
Programs that we teach in:
Epidemiology and Clinical Research Graduate Certificate Program
Find us on:
Kristin - LinkedIn & Twitter/X
Regina - LinkedIn & ReginaNuzzo.com
- (00:00) - Intro
- (02:26) - Mailbag
- (06:42) - P-values
- (12:43) - Multiple Testing Guy
- (16:05) - Bonferroni solution
- (17:11) - Post hoc analysis ex
- (22:22) - Subgroup analysis person
- (29:34) - Statistical adjustment idealist
- (43:00) - Unmeasured confounding
- (44:25) - Residual confounding
- (48:31) - Over-adjustment
- (53:48) - Wrap-up
19 episodes
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