In this Nursing World Shared Practice Forum Podcast, Dr. Bernadette Melnyk, a globally renowned expert in evidence-based practice (EBP), discusses the critical importance of EBP in healthcare. This podcast covers the history of EBP, its impact on patient outcomes, and the return on investment for healthcare systems. Dr. Melnyk shares insights on building a culture that supports EBP, the role of EBP mentors, and the importance of clinician well-being. LEARNING OBJECTIVES - Identify strategies for creating and sustaining a culture that prioritizes EBP within healthcare organizations - Recognize the role of EBP mentors in facilitating the implementation of evidence-based changes - Explore the relationship between EBP, clinician well-being, and job satisfaction - Understand the organizational benefits of EBP initiatives as measured by return on investment (ROI) and value of investment (VOI) - Learn the difference between EBP and Implementation Science AUTHORS Bernadette Melnyk, PhD, APRN-CNP, EBP-C, FAANP, FNAP, FAAN CEO and Founder, COPE2Thrive, LLC President and Co-Founder, EBP Solutions, LLC Professor and Dean Emeriti Editor-in-Chief, Worldviews on Evidence-based Nursing Ethan Schuler, DNP, RN, CPNP-AC/PC, APN II Surgical Nurse Practitioner, Division of Critical Care Medicine Boston Children's Hospital DATE Initial publication date: November 18, 2025. ARTICLES REFERENCED 1) Melnyk BM, Strait LA, Beckett C, Hsieh AP, Messinger J, Masciola R. The state of mental health, burnout, mattering and perceived wellness culture in Doctorally prepared nursing faculty with implications for action. Worldviews Evid Based Nurs. 2023;20(2):142-152. doi:10.1111/wvn.12632 2) Melnyk BM, Hsieh AP, Tan A, et al. Associations Among Nurses' Mental/Physical Health, Lifestyle Behaviors, Shift Length, and Workplace Wellness Support During COVID-19: Important Implications for Health Care Systems. Nurs Adm Q. 2022;46(1):5-18. doi:10.1097/NAQ.0000000000000499 3) Melnyk BM, Davidson JE, Tucker S, et al. Burnout, Mental Health, and Workplace Characteristics: Contributors and Protective Factors Associated With Suicidal Ideation in High-Risk Nurses. Worldviews Evid Based Nurs. 2025;22(3):e70042. doi:10.1111/wvn.70042 4) Melnyk BM, Hsieh AP, Messinger J, Thomas B, Connor L, Gallagher-Ford L. Budgetary investment in evidence-based practice by chief nurses and stronger EBP cultures are associated with less turnover and better patient outcomes. Worldviews Evid Based Nurs. 2023;20(2):162-171. doi:10.1111/wvn.12645 TRANSCRIPT Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access thus at no expense to the user. For further information on how to enroll, please email: [email protected] CITATION Melnyk BM, Schuler E, DeGrazia M. Transforming Healthcare with Evidence-Based Practice. 11/2025. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/transforming-healthcare-with-evidence-based-practice-by-b-melnyk-openpediatrics.