In this episode of Research Renaissance, host Deborah Westphal sits down with Dr. Alberto Serrano-Pozo, Assistant Professor of Neurology at Harvard Medical School, staff neurologist at Massachusetts General Hospital, and a 2022 Toffler Scholar. Together, they explore Dr. Serrano-Pozo’s pioneering research into the role of glial cells—specifically astrocytes—and the APOE gene in the development and progression of Alzheimer’s disease.

Dr. Serrano-Pozo discusses how astrocytes, long overlooked in favor of neurons, are now recognized as key players in maintaining brain health—and how their dysfunction may contribute to Alzheimer's pathology. The conversation also covers the complexities of the APOE gene variants, how recent discoveries are reshaping our understanding of Alzheimer's across different populations, and promising advances in gene-editing research.

Dr. Serrano-Pozo also reflects on the dual role he plays as both a researcher and a clinician, how patient interactions inspire his lab work, and why cautious optimism is warranted as new therapies and technologies emerge.

What You'll Learn:

• Why astrocytes are crucial to brain function—and how they change in Alzheimer's
• The evolving understanding of the APOE gene’s role in Alzheimer's risk
• How glial cells interact with amyloid plaques and tau tangles
• Why certain APOE variants affect populations differently
• Advances in gene-editing that may offer future protection against Alzheimer's
• The real-world challenges and rewards of balancing clinical practice with research
• A hopeful look at the accelerating pace of Alzheimer's research and innovation

Key Quotes:
🧠 "If we can understand how astrocytes get sick, maybe we can fix them—and slow the progression of Alzheimer's."
🧬 "APOE is like a messenger between brain cells—and one small genetic variation can change everything."
🌎 "There's more collaboration, more knowledge-sharing, and more technological advancement than ever before. We should remain cautiously optimistic."

Learn More:
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To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org.
Technical Podcast Support by Jon Keur at Wayfare Recording Co.