This episode contains part 2 of our conversation with Michael Macklin, MD, PharmD, Assistant Professor of Medicine at the University of Chicago, about the Cytokine Crushers region of RheumMadness 2025.
In this episode, we focus specifically on the TYK2 in SLE and Oral Anti-IL23 teams.
Links to the Cytokine Crushers Scouting Reports:

• Oral anti-IL23, by collaborating Chicago area rheumatology fellowship programs (Loyola, Northwestern, and the University of Chicago)
• Long-term outcomes of anifrolumab in SLE, by the Medical University of South Carolina (MUSC) Adult Rheumatology Fellowship
• TYK2 inhibitor in SLE, by the University of North Carolina (UNC) Adult Rheumatology Fellowship

Links to theMednet.org Q&As about this region:

• What circumstances would drive you to consider using an oral IL-23 inhibitor over parenteral options for management of psoriasis/PsA?
• How will you utilize newly FDA approved anifrolumab for SLE in your practice?
• What is your experience with using oral deucravicitinib for conditions such as recalcitrant facial discoid lupus or recalcitrant lichen planus?

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Intro/outro music: Cheery Monday by Kevin MacLeod
Link: https://incompetech.filmmusic.io/song/3495-cheery-monday
License: http://creativecommons.org/licenses/by/4.0/