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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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Episode Outline: Why Retatrutide Isn’t for Everyone
1. Overview
- What retatrutide is and why it’s generating hype
- Quick reminder it’s still investigational
2. Nervous System & Cardiovascular Effects
- Increased resting heart rate
- Lower HRV and sympathetic activation
- Why certain people feel “revved up”
3. Sleep Disruption
- Trouble falling asleep
- Light, fragmented sleep
- “Wired but tired” pattern linked to HRV + stress hormones
4. Increased Hunger on Retatrutide
- Why some experience more hunger vs. tirzepatide
- Inconsistent appetite suppression
- Glucagon receptor activation + stress = stronger hunger signals
5. Difficulty Switching From Tirzepatide
- Rebound hunger during the transition
- Loss of steady appetite control
- Early retatrutide dosing not matching tirzepatide stability
6. Individual Variability
- Stress levels, hormones, genetics, and titration pace all change response
7. Key Takeaway
- Retatrutide is powerful but not universally tolerated
- HRV, hunger, sleep—your body’s feedback matters
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