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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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In this episode, we dive into groundbreaking research on GLP-1s and other hunger hormones and how a clinically studied plant compound is helping women reduce cravings, improve appetite control, and support fat loss—naturally. You'll learn how bitter compounds work with your gut-brain axis, why your hunger hormones may be out of sync, and how this New Zealand–funded discovery is changing the game for women coming off GLP-1 injectables like semaglutide or tirzepatide.
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🔑 KEY TOPICS 🔑
-GLP-1, CCK & PYY: how they control hunger
-Bitter compounds and the gut-brain axis
-Clinical trial results on female hunger and cravings
-Supporting women off GLP-1 injections
-Protein, probiotics, and stacking supplements for appetite
🕐 TIMESTAMPS 🕐
[00:00] Why hunger isn't about willpower: The role of ghrelin and the hindbrain
[03:00] Government-funded research on natural appetite suppressants from bitter compounds
[10:15] How GLP-1, CCK, and PYY regulate appetite and fat loss through the gut-brain axis
[16:00] Women’s unique hormonal response to GLP-1 and why female trials matter
[20:30] Reducing cravings and calorie intake during PMS and the luteal phase
[27:30] Transitioning off GLP-1 injectables with natural gut-based solutions
[34:00] Best supplements to stack with Calocurb: protein, probiotics, amino acids
[40:00] Clinical results on weight loss, fat vs muscle, and upregulating GLP-1
[43:00] How to spot scammy weight loss supplements vs real research-backed solutions
🎙️Guest: Sarah Kennedy🎙️
Website: https://www.calocurb.com/10OFF
👉 Get 10% off, use discount code: 10OFF to purchase Calocurb
🌐 LET'S CONNECT 🌐
Host: Orshi McNaughton
Podcast Links: https://linktr.ee/optimizedwomen
Website: https://www.optimizedwomen.com/
YouTube Channel: https://www.youtube.com/@optimizedwomen
Instagram: https://www.instagram.com/optimizedwomen
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