Welcome to another episode of the gIDE Unlocked Podcast, hosted by Dr. Sascha Jovanovic from the gIDE Institute in Los Angeles. In this episode, filmed in the heart of Florence, Italy, Dr. Jovanovic sits down with world-renowned implant pioneer Prof. Massimo Simion — one of the founding fathers of guided bone regeneration (GBR) and a true legend in implant and regenerative dentistry.

Together, they revisit 40 years of clinical experience, research, and innovation — discussing the evolution of biomaterials, the balance between autogenous bone and graft substitutes, and how today’s clinicians can avoid common mistakes when performing regeneration procedures.

• The truth about biomaterials — which ones actually work and which don’t

• Why autogenous bone remains the gold standard for large augmentations

• The right ratio of autogenous chips vs. biomaterials for predictable GBR

• Key differences between xenografts and allografts — and when to use each

• Why long-term stability depends on resorption rate and material selection

• The biological risk of leaving too much xenograft in regenerated bone

• When to choose xenograft for augmentation vs. allograft for peri-implantitis or intrabony defects

• A powerful message to young clinicians: master surgery before relying on digital guidance

• Prof. Simion’s philosophy on clinical skill, evidence-based decision-making, and lifelong learning

This is a masterclass in biological principles, surgical judgment, and critical thinking from one of dentistry’s most respected voices.

🎥 Watch the full conversation to hear Prof. Simion and Dr. Jovanovic share insights on the past, present, and future of regenerative implant dentistry — from GBR to biomaterials to digital workflows.

🔔 Subscribe to gIDE Unlocked for more interviews with the world’s leading experts in implant dentistry, bone regeneration, soft-tissue management, GBR, IDR, and esthetic reconstruction. 🌐 Explore advanced online and hands-on programs at gidedental.com