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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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Manage episode 522668885 series 3704940
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Citation (Vancouver):
Lee D, Lee H, Lee C, Lee C. The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial. Anesth Analg. 2025;XXX(00):00-00. doi:10.1213/ANE.0000000000007818.
Study at a glance
- Design and setting: Single-centre, double-blinded 2×2 factorial RCT in adults (n=188) having elective upper extremity surgery under brachial plexus block with IV sedation (Republic of Korea).
- Interventions: Propofol vs ketamine sedation, each with or without standardised preoperative positive suggestions about pleasant dreams (four groups of 47 patients).
- Primary outcome (drug-induced dream recall, DIDR): Dreams were recalled in about 23% with propofol (22/94) vs 40% with ketamine (38/94); ketamine increased the odds of DIDR compared with propofol (OR 2.14, 95% CI 1.23–3.72; p=0.007; moderate-certainty evidence).
- Effect of suggestions: Preoperative positive suggestions did not clearly increase overall dream recall (OR 1.16, 95% CI 0.67–2.01; p=0.598), though they may have influenced qualitative dream characteristics.
- Key secondary: Patient satisfaction with sedation was high overall but lower with ketamine than propofol (approximately 82 vs 93–95 out of 100).
- Safety and bias: Sixteen patients (8.5%) discontinued sedation because of hypoxia, hypotension, or hypertension; missing DIDR data were imputed as ‘no dream’. Overall risk of bias was judged as “some concerns,” and certainty for the main DIDR result was rated moderate.
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