Sebastian Maniscalco is a stand-up comedian and actor whose family-driven humor and razor-sharp delivery have made him one of the most recognizable voices in comedy. In this sitdown from December 2022, Sebastian talks with Willie Geist about the real-life moments that inspire his act, his stand-up special Is It Me? and the surreal experience of watching Robert De Niro portray his father in About My Father. Plus, he reflects on his long climb from open mics to arena tours, the influences that shaped his point of view, and why family remains at the center of everything he does.