Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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Episode 63: Unlocking the Secrets of T Cell Therapy Resistance
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Manage episode 375689946 series 1936276
Content provided by TGen Talks. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by TGen Talks or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
For a patient diagnosed with multiple myeloma, a type of blood cancer, there are more treatment options than ever and traditional chemotherapies that cause debilitating side effects have been all but completely replaced by immunotherapies, treatments that help a patient's own immune system better fight the disease. But in many patients, a chosen immunotherapy drug can show great promise in early treatments, yet seemingly stop working altogether as time goes by. In a paper that was published in Nature Medicine, TGen's Dr. Jonathan Keats explains how upwards of 65% of relapsing multiple myeloma patients could be affected by mutations that impact targeted T cell treatments. On this episode, you'll hear about a study that found how these cancer cells were mutating to evade the very drugs prescribed to fight them. The findings could help clinicians and patients choose from among a variety of T cell therapies for multiple myeloma to find treatments that best match a patient’s available tumor targets. Dr. Keats also discusses his broader work in multiple myeloma and plans for a rapid sequencing center that will place valuable genomic-informed data in the hands of treating physicians in just 48 hours. All this and more on TGen Talks.
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86 episodes
MP3•Episode home
Manage episode 375689946 series 1936276
Content provided by TGen Talks. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by TGen Talks or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
For a patient diagnosed with multiple myeloma, a type of blood cancer, there are more treatment options than ever and traditional chemotherapies that cause debilitating side effects have been all but completely replaced by immunotherapies, treatments that help a patient's own immune system better fight the disease. But in many patients, a chosen immunotherapy drug can show great promise in early treatments, yet seemingly stop working altogether as time goes by. In a paper that was published in Nature Medicine, TGen's Dr. Jonathan Keats explains how upwards of 65% of relapsing multiple myeloma patients could be affected by mutations that impact targeted T cell treatments. On this episode, you'll hear about a study that found how these cancer cells were mutating to evade the very drugs prescribed to fight them. The findings could help clinicians and patients choose from among a variety of T cell therapies for multiple myeloma to find treatments that best match a patient’s available tumor targets. Dr. Keats also discusses his broader work in multiple myeloma and plans for a rapid sequencing center that will place valuable genomic-informed data in the hands of treating physicians in just 48 hours. All this and more on TGen Talks.
…
continue reading
86 episodes
All episodes
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