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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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What if the real path to longevity is mastering fundamentals while measuring what matters?
In this episode, recorded at Copenhagen Health Week, Siim Land - author, longevity educator, and anthropology graduate - breaks down a pragmatic roadmap to living longer and better. We get honest about diet debates, biomarkers, and what to do before you touch a single peptide or pharmaceutical.
We cover why adaptation defines human health, how to use blood work and objective markers to see risk decades ahead, the case for sleep, movement, diet, and environment, and where rapamycin, metformin, and methylene blue actually fit. Siim shares his supplement stack, the VO2 max trade-offs with creatine, and a grounded outlook on gene editing, embryo selection, and the ethics of enhancement.
📌 What You Will Learn
• Adaptation, anthropology, and why context matters
• Diet through the biomarker lens, not dogma
• The four fundamentals that move the needle
• Rapamycin, metformin, methylene blue: promise vs proof
• Siim’s stack and why he keeps it simple
• VO2 max, creatine, and training trade-offs
• Social connection and purpose as longevity inputs
• Gene editing timelines and ethical questions
• A clear framework for risk in the “escape velocity” era
⏱ Timestamps
0:00 – The hidden health crisis and why prevention wins
1:12 – Siim’s path: fitness to anthropology to longevity
4:12 – Humans adapt, and that changes the rules
9:58 – Diet diversity, sensitivities, and n of 1
16:51 – Assess first: biomarkers that predict disease risk
18:27 – Fixing sleep, movement, diet, environment
22:47 – Caution on rapamycin, metformin, methylene blue
25:54 – FOXO3 stem-cell study and what it means
37:15 – Mindset and willpower as real enhancers
41:44 – TMG, astaxanthin, melatonin, creatine
47:09 – VO2 max priorities and performance trade-offs
48:51 – Balancing fitness with joy and purpose
53:18 – Biomarkers mediate risk more than labels
1:01:00 – 2030–2040: what is realistic
1:04:02 – Immortality probabilities and living well now
1:12:10 – Final thoughts
🎙 Hosted by Julian Issa
📸 Instagram: @thebeyondtomorrowpodcast
🌐 Website: www.beyondtomorrowpodcast.com
📩 Email: [email protected]
🎧 Follow on Spotify, Apple, and YouTube for more future-focused conversations.
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