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When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
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As drug development pushes into more complex antibody formats, the big question is: how do you really assess developability? In this episode, host Nimish Gera speaks with Shamit Shrivastava, Ph.D., founder and CEO of Apoha, to dive into Liquid Brain, his interdisciplinary innovation that’s changing the way researchers tackle developability of challenging antibody-based drugs. Shamit breaks down what makes Liquid Brain different from traditional developability methods, reveals how it’s unlocking new possibilities for complex format development, and shares a glimpse into Apoha’s future-including an exclusive preview of what’s coming at PEGS Europe this November.
Chapters
1. Opening & Guest Introduction (00:00:00)
2. Data Deluge in Biology (00:01:05)
3. Academic Roots to Startup Leap (00:02:45)
4. Mechanical Waves as Biological Signals (00:04:05)
5. From Membranes to Antibody Delivery (00:06:20)
6. The Liquid Brain Concept (00:08:20)
7. System Architecture & Automation (00:11:05)
8. Why Developability First (00:13:20)
9. Differentiation vs Traditional Assays (00:15:30)
10. Complex Formats: BsAbs and ADCs (00:18:10)
11. State Diagrams as a Third Pillar (00:21:05)
12. Properties as Features of Behavior (00:24:10)
13. Collaboration Models & Access (00:26:00)
14. Roadmap: Explainability, Ecosystem, Deployment (00:29:00)
15. Upcoming Benchmarks & Conference Plans (00:31:20)
16. Closing Thoughts & Listener CTA (00:33:00)
81 episodes
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