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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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Pollution isn’t an abstract headline; it’s inside our bodies today. We sit down with Dr. Jenna Hua to reveal how small, everyday choices expose us to hormone-disrupting chemicals. Jenna explains why single-chemical research fails in a world of mixed exposures and shows how metabolomics turns invisible toxins into clear, personal insights you can act on now.
We trace Jenna’s path from nutrition research and a Fulbright in China to a painful fertility journey that exposed the limits of clinical testing. That lived experience powered a new model: targeted urine testing for bisphenols, phthalates, parabens, oxybenzone, and other chemicals, paired with education that helps you ditch high-exposure products and rethink packaging, takeout, and personal care. We also go behind the scenes on what it takes to make real-world science work: building shippable kits, solving messy logistics, and funding rigorous studies through SBIR grants when traditional investors wanted a simpler story.
Then we look forward. With the Healthy Nevada Project, Jenna’s team is connecting exposure profiles to genetics to understand who detoxes quickly, who bioactivates toxic intermediates, and how reducing exposure can change clinical outcomes in fertility, weight, and metabolic health. We break down targeted vs untargeted metabolomics, and why automation, AI, and product testing are the next frontier for honest labeling and safer supply chains. If you’ve wondered whether phthalate-free really means what it says, or how to make weight-loss therapy more effective by lowering obesogens, this conversation delivers science, strategy, and a roadmap you can use.
If this resonated, share it with a friend, subscribe for more climate biotech deep dives, and leave a review to help others discover the show. Your support helps bring rigorous, human-centered science to the problems that affect us all.
To learn more, check out:
Website: www.millionmarker.com (main company site)
Million Marker Research Institute: millionmarker.org (nonprofit side with white papers on product testing)
Chapters
1. Why Single-Chemical Studies Fail (00:00:00)
2. Meet The Host And Mission (00:00:15)
3. Introducing Dr. Jenna Hua (00:00:41)
4. Jenna’s Roots And Early Research (00:02:07)
5. From Nutrition To Exposure Science (00:03:08)
6. Metabolomics And The Streetlight Problem (00:05:13)
7. Why “Million Marker” Exists (00:07:34)
8. Founding Story And Fertility Struggles (00:09:13)
9. YC, Funding Gaps, And Real-World Data (00:12:57)
10. Building A Usable At-Home Urine Test (00:16:15)
11. Surviving As A Science Startup (00:20:02)
12. State Partnerships And Causality Studies (00:22:43)
13. Obesogens, Diabetes, And Weight Loss Drugs (00:24:19)
14. Targeted vs Untargeted Metabolomics (00:26:05)
15. Why Urine Is The Best Matrix (00:28:10)
16. Gene–Environment Interactions In Nevada (00:30:20)
17. Persistent Chemicals And Limits Of Action (00:33:22)
18. Transgenerational Risks And Mechanisms (00:36:00)
19. Tech Wish List And Automation (00:38:10)
20. Product Testing And Supply Chain Truth (00:41:00)
21. Rapid Fire: Mentors, Exposome, Communication (00:44:50)
22. Where To Learn More And Closing (00:49:30)
28 episodes
