In this episode, Dr. Jeremy Koenig speaks with Dr. Ryan Rossner, Director of Longevity at Minicircle, about non-viral gene therapy, its implications for muscle restoration, fighting inflammation, and extending health span. Dr. Rossner shares insights into the science behind plasmid gene therapy, its unique approach compared to traditional methods, and the future possibilities of harnessing DNA for enhanced human potential.

Key Takeaways:

• Non-Viral Gene Therapy: Minicircle uses a plasmid-based approach to deliver therapeutic genes without viruses, reducing safety risks while effectively integrating into human cells.
• Follistatin Therapy: This gene therapy targets lean muscle growth and anti-inflammatory benefits by increasing the expression of Follistatin, offering a promising alternative to growth hormones and testosterone.
• Localized Delivery with Systemic Impact: Injecting plasmids into belly fat cells creates a localized protein factory that delivers systemic health benefits.
• Future of Gene Therapy: Minicircle is exploring therapies for cognitive enhancement (Klotho) and muscular dystrophy, pushing the boundaries of genetic interventions.
• Decentralized Medicine: The rise of medical tourism and decentralized research models could democratize access to advanced therapies.
• Philosophy and Biology: The conversation dives deep into the philosophical implications of gene editing, questioning whether DNA is a fixed code or an evolving blueprint we can co-create with.
• Light-Based Biology: Emerging technologies that use light to enhance mitochondrial function hint at revolutionary methods of energy production and healing.

Connect with Dr. Ryan: https://www.instagram.com/rjrphd/

LINKS:
https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig

Here's the link for this week's episode: https://drjeremykoenig.substack.com/.