Abstract: This research brief examines how person-job fit (P-J fit) and person-organization fit (P-O fit) moderate the relationship between workplace spirituality and employee physical and mental health outcomes. Drawing on empirical research and professional consulting experience, the analysis reveals three primary moderation patterns: an amplification effect, where high P-J and P-O fit strengthen the positive health impacts of workplace spirituality; a buffering effect, where strong fit dimensions protect employee well-being even when workplace spirituality is low; and a substitution effect, where fit experiences partially compensate for limited spiritual dimensions in the workplace. The brief offers evidence-based strategies for organizations to leverage these relationships through integrative recruitment processes, job crafting initiatives, cultural congruence programs, and holistic well-being approaches that address the interplay between spirituality, fit, and health. Organizations that effectively harmonize these dimensions create environments where employees experience greater alignment between personal values, job responsibilities, and organizational culture, resulting in enhanced well-being outcomes and organizational performance.