Physician, conservationist and former U.S. Senate Majority Leader Senator Bill Frist shares his remarkable journey of hope and leadership. From pioneering life-saving medical procedures to breaking barriers in the Senate as the only physician in the chamber in 65 years, Frist reveals how a foundation of compassion, resilience and science guided his path from the operating room to policymaking. In this episode, he discusses how evidence-based decision-making, deep collaboration and a steadfast commitment to global health have shaped major initiatives—from crisis response to international healthcare reforms—leaving an enduring legacy of service and transformative change.