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“The goal isn’t just to lose weight. It’s to have a strong metabolism for the long haul.” - Leslie Duffy

Whether you’re on a GLP-1 medication, considering it, or just curious about how it works, one thing is clear: these drugs are everywhere right now. For many women in midlife, they’ve been life-changing, helping quiet food noise, steady blood sugar, and making weight loss possible for the first time in years. But as empowering as that can feel, there are real challenges that we hardly hear about, from nutrient deficiencies and digestive issues to muscle loss, and a slower metabolism that’s hard to rebuild later on.

Today, I’m sharing a practical, science-backed toolkit to help you protect your health while you’re on GLP-1s and for the long term. You’ll learn what labs to ask your doctor about, how to prevent constipation, the importance of prioritizing protein and fiber, how to keep your digestion and energy steady even when your appetite drops, why movement and strength training matter more than ever, how to support your microbiome, the key supplements that can help maintain muscle and hormone balance during your journey, and more.

By the end of this episode, you’ll have a plan to use these medications safely, preserve your long-term metabolic health, and feel confident that you’re supporting your body, not depleting it.

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Your Takeaways

Why GLP-1 shots can cause both progress and new problems

The hidden cost of weight loss (muscle, bone, and nutrient loss)

How slow digestion and low fiber intake worsen constipation and bloating

The must-have nutrients for women on GLP-1s: protein, magnesium, iron, zinc, B12

How to protect metabolism and digestion with strength training, enzymes, and fiber

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Episode Resources

Get your FREE Functional Medicine GLP-1 Toolkit https://leslie-duffy-coaching.kit.com/a65bb7d370

Check out the full show notes at https://leslieduffycoaching.com/13

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Connect with Leslie

Connect with me and learn more at LeslieDuffyCoaching.com (https://leslieduffycoaching.com/)

Send me a message and follow me on Instagram @LeslieDuffyCoaching (https://www.instagram.com/leslieduffycoaching/)

Watch the video version of this episode on YouTube @TheHormoneShiftShow (https://www.youtube.com/@TheHormoneShiftShow)

I love hearing from listeners! Email your questions or topic requests to [email protected]

Check out Leslie’s favorite things: Amazon Storefront (https://www.amazon.com/shop/leslieduffycoaching)

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14 episodes