Lionel delves into a sprawling array of subjects, from personal ailments (the agony of a cracked lip) to unusual religious traditions including snake handling in West Virginia, the cargo cults of Papua New Guinea, and the forgotten practice of sin eaters. The discussion moves rapidly to critical health and nutrition debates, questioning the efficacy of diets like Carnivore/Keto, emphasizing the dangers of frying, criticizing the lack of nutritional education in medicine, and highlighting concerns about GMOs and dairy casein. Lionel connects diet to modern disease and socioeconomic factors while fielding calls on the atomic history of Einstein and Szilard and the philosophical implications of fast food's "guaranteed happiness".

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