In this episode of The SHEA Podcast, host Dr. Jonathan Ryder (University of Nebraska Medical Center) speaks with Dr. Aditi Ramakrishnan (Washington University in St. Louis) about how antimicrobial stewardship programs can play a vital role in managing and preventing resistant sexually transmitted infections. They explore the challenges and opportunities at this intersection — from the promise and controversy surrounding doxycycline post-exposure prophylaxis (DoxyPEP), to the debate over routine STI screening among populations on PrEP, and the broader stewardship considerations beyond antibiotic use.