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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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In this episode of The Uprising Show, host Vivek sits down with Manush Saydmohammed, Ph.D., MBA, co-founder and CEO of ZEGENEX Inc., a Pittsburgh-based startup developing innovative wound healing solutions. Manush shares his remarkable journey from humble beginnings in Kerala, India, through a career in biomedical research across India, Japan, and the US, to becoming an entrepreneur driven by the desire to translate cutting-edge science into real-world medical solutions.
The conversation dives into how the COVID-19 pandemic inspired Manush to transition from academic research to the world of startups, and explores the science behind ZEGENEX’s groundbreaking small-molecule cream designed to accelerate healing in chronic wounds like diabetic foot ulcers. Manush candidly discusses the challenges of moving novel therapies from the lab to the clinic, the importance of patents and collaboration, and the regulatory hurdles unique to new drug entities.
They also touch on the exciting future of health tech, from AI-accelerated drug discovery to gene editing and personalized medicine. Manush closes by sharing personal insights on entrepreneurship, including the importance of mindset, adaptability, and the inspiration he draws from innovators like Mark Cuban. Whether you’re passionate about science, startups, or healthcare innovation, this episode offers an inspiring look into the entrepreneurial journey and the potential to make a real impact in patient care.
Timestamps:
00:00 From Kerala to the US: Research Journey
04:24 Navigating Transitional Unlearning
07:08 Pioneering Treatment for Chronic Wounds
11:44 Product Success: Feasibility and Viability
16:04 Zebrafish: Ideal Heart Regeneration Model
19:45 Patents Ensure Product Credibility
22:43 New Drug Device Regulatory Pathway
26:46 AI in Drug Discovery
30:27 Stem Cell Industry Exploration
31:33 Diabetic Foot Ulcer Study Phases
36:50 Change Habits, Mark Cuban Inspiration
38:30 "Challenging Fundraising, Hopeful Future"
The Uprising Show Website: https://theuprisingshow.com/
Vivek Nanda's LinkedIn: https://www.linkedin.com/in/viveknanda1/
Vivek Nanda's Twitter: https://x.com/vickks
TopHealth Media Website: https://tophealth.care/
33 episodes
