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In this episode of Unshielded: A Blockchain & Data Podcast by Midnight, host Ian Kane is joined by Demetrios Skalkotos, Chief DeFi and Protocol Officer at Blockdaemon, to unpack how enterprise-grade infrastructure is reshaping decentralized finance. From securing digital assets across 400+ institutions to integrating privacy-first technologies, Demetrios shares the real challenges and opportunities driving adoption at scale.
What You’ll Learn:

  • How to design a security architecture that never compromises
  • Why institutional clients demand something fundamentally different from retail
  • The unified API framework for solving DeFi fragmentation
  • How rational privacy enables institutional participation in DeFi
  • The go-to-market advantage of consolidating your vendor stack
  • How institutional DeFi will integrate with TradFi to become the new normal in finance
With a career spanning traditional finance infrastructure at NASDAQ and NYSE, coupled with foundational roles at Ledger and Blockdaemon, Demetrios brings deep expertise in institutional blockchain infrastructure, custody solutions, and DeFi protocol integration.
If you enjoyed this episode, make sure to subscribe, rate, and review it on Apple Podcasts, Spotify, and YouTube Podcasts. Instructions on how to do so are here.

Episode Resources:


This episode is brought to you by Midnight.
To learn more about the Midnight Network, visit the website at https://midnight.network/
Join the Midnight Discord: https://discord.com/invite/midnightnetwork

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19 episodes